... peroxidase labelling,density increasing of the Z-line, in particular at the edges of the structure, confirms the immunofluorescentstaining. On the other hand, labelling of the Z-bandregion by CP1 ... thoselocating calpain 1 at the midpoint of the I-band, pro-vide reasonable evidence to support the interaction of the protease within the 800 kDa fragment. The binding interaction of calpain 1 with ... Consequently, the colocalization of calpain 1 and calpain 3 at N1- and N2-line levels, the postmortem fractures at the N2-linelevel, as well as the implication of titin in the bindingto calpain 3 [20] and...