Báo cáo khoa học: The mystery of nonclassical protein secretion A current view on cargo proteins and potential export routes pdf
Báo cáo khoa học: The mystery of nonclassical protein secretion A current view on cargo proteins and potential export routes pdf
... biochemicalanalysis of the export apparatus. It is also a major problemthat, in most cases, only very limited information isavailable about the motifs that target cargo proteins to the nonclassical ... proteins in mammalian cells revealed the existence of a machinery that is capable of translocating the protein across the plasma membrane [103], demonstrating a conserved pathway among lower and higher ... related to that of bacterial ABCtransporters that mediate protein secretion of, for example,hemolysin [32–34].Fig. 1. Cargo proteins and potential export routes of unconventional protein secretion. ...
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Báo cáo khoa học: The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmacology pptx
... interaction. (A) The sequential binding of the ligands to each half of the receptordimer induces the recruitment of twomolecules of b-arrestin and then the activation of ERK. (B) Only one molecule of ... plasma membrane and tostimulate ERK1 ⁄ 2 phosphorylation. All these dataindicate quite clearly that homo-oligomerization and hetero-oligomerization have a pivotal role in defining the GPCR–b-arrestin ... specificity, and consequently indetermining the receptor fate and b-arrestin-mediatedMAPK activation.As discussed above for G -proteins, the mechanism and the stoichiometry by which GPCR and b-arrestininteract...
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Tài liệu Báo cáo khoa học: "THE REPRESENTATION OF INCONSISTENT INFORMATION IN A DYNAMIC MODEL-THEORETIC SEMANTICS" ppt
... addition of information to the model. This interaction of the evaluation of a formula and the expansion of the model produces several linguistically interesting side-effects, and these have ... evaluates a formula with respect to a model has been augmented with a table that contains each ~-expression and the ima6e of its denotation in the current stage of the dynamic model. When the domain ... talking, or vice versa. If such an expansion were made, the inconsistency would exist only in the evaluation of that particular formula, and not in the model. Subsequent evaluations of the...
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Báo cáo khoa học: The propagation of hamster-adapted scrapie PrPSc can be enhanced by reduced pyridine nucleotide in vitro pdf
... includinganaesthetic and surgical procedures, as well as animal man-agement, have been reviewed and approved, and wereperformed in accordance with the relevant China nationallegislations and regulations.Recombinant ... blot analysis showed that the effi-ciency of PrPScpropagation was enhanced by the addition of NADPH, which was closely related toincreasing NADPH concentrations (Fig. 4A, comparelane 1 and lanes ... of the reactions of 0 and 10 lm NADPH revealed that the efficiency of PMCAwas increased by 2.59-fold in the presence of NADPH. To evaluate whether the effect of NADPH on PrPScpropagation was...
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Báo cáo khoa học: The binding of IMP to Ribonuclease A pptx
... binding at the active site of RNase A. The r.m.s.d. between the RNase–AMP complex and the unliganded protein are0.43, 0.44 and 0.59 A ˚for the Ca, main chain and sidechain atoms of 123 equivalent ... Rfreevalue. The second AMP conformationhas the phosphoryl group away from the P1subsite and as it is a minor conformation it was not includedin the structural comparisons. The conformation of AMP ... in the unbound and protein bound adenosines [32]. The glycosyl torsion angle v adopts the anti-conformation and the rest of the backbone and phosphate torsionangles are in the preferred range...
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Báo cáo khoa học: The use of recombinant protein and RNA interference approaches to study the reproductive functions of a gonad-stimulating hormone from the shrimp Metapenaeus ensis ppt
... primers(forward, 5¢-TAATACGACTCACTATAGGTACTATGTATCGCATGCCAAT-3¢; reverse, 5¢-TAATACGACTCACTATAGGTACTTTAAAGTCCCGGGTTGA-3¢). ForPCR, the reaction mix consisted of 1 · Taq buffer contain-ing 1.5 ... the tiger prawn Penaeus monodon. As there is a high degree of sequence similarity and structural conservation of these genes and gene products, confirmation of the trueidentity and function of ... function analysis by RNAi maybe advantageous as compared to other conventionalapproaches. This article describes the production of recombinant protein and dsRNA for reproduction-related eyestalk...
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Báo cáo khoa học: The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics doc
... probe the functional effects of dimeriza-tion ⁄ oligomerization on mechanisms of ligand binding and extent of activation (i.e. pharmacological efficacy),as well as on the involvement of protein protein ... information can be used to predict pro-bable regions involved in protein protein interactions.Many of the limitations and considerations of accuracy and reliability of these methods have been reviewedrecently ... inter-actions in GPCR function (e.g. transactivation).Methods employed The evolutionary trace method The evolutionary trace method is an adaptation of anearlier strategy for the hierarchical analysis...
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Tài liệu Báo cáo khoa học: The occurrence of hemocyanin in Hexapoda docx
... Plecoptera, Dermaptera, Orthop-tera, Phasmatodea, Mantodea, Isoptera and Blattaria,but not in Protura, Diplura, Ephemeroptera, Odonata and the Eumetabola (Holometabola + Hemiptera)(Fig. 3). In addition, ... Hexapoda and provides strong evidencefor the monophyly of the Polyneoptera (Plecoptera, Dermaptera, Orthop-tera, Phasmatodea, Mantodea, Isoptera, Blattaria) and the Dictyoptera(Mantodea, Isoptera, ... Juvenile, adult – –Machilis germanica Archeognatha Machilidae Adult MgeHc1 –Ephemerella mucronata Ephemeroptera Ephemerellidae Juvenile – –Aeshna cyanea Odonata Aeshnidae Adult – –Locusta migratoria...
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Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf
... (DTT), aggregation and precipitation of a- lactalbumin commenced after25 min and reached a plateau after 90 min. The amount of DTT-induced aggregation of a- lactalbuminwas increased in a concentration-dependent ... ordered and disordered protein aggregationHeath Ecroyd and John A. CarverSchool of Chemistry and Physics, The University of Adelaide, Australia Protein aggregation is the result of the mutual associa-tion ... incu-bated at 37 °Cin50mm phosphate buffer, pH 7.2, contain-ing 100 mm NaCl, and aggregation and precipitation wasinitiated by addition of DTT to a final concentration of 20 mm (a- lactalbumin)...
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Tài liệu Báo cáo khoa học: The sequentiallity of nucleosomes in the 30 nm chromatin fibre pptx
... digestion of the DNA to mononucleosome size of samples con-sisting of a mixture of hepta-, octa- and nonanucleosomes and half the amount of hexa- and decanucleosomes (6- to 10-mer sample). (A) (a) Nonamer ... mononucleosomes and the band S. DNA gel electrophoresis of the fractionsfrom Fig. 3D,E showed that approximately 90% of the DNA in the main peak as well as the mononucleo-somes and band S are all in the ... histones on the chromato-some and found that only the mononucleosome frac-tion loses some of the linker histones. The ratio of H5to H4 histones (which have similar abundances and can be assessed...
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