... substrate; JAK-STAT, janus kinase-signal transducer and activator of tran-scription, mitogen-activated protein kinase; LPS, lipopolysaccharide; MAPK, mitogen-activated protein kinase; MCF, macrophare ... acetateassimilation are needed as a resultof a coupling between the TCA cycleand acetate activation to acetyl-CoAby acetyl-CoA transferaseStoich FBA, opt,MOMA,FVA, SNANG NG Time series of enzymeactivities ... (ischemia) of key metaboliteconcentrations and metabolic fluxes,both measured and nonmeasured. A general parameter sensitivityanalysis is carried out to determineand characterize the parametershaving...