Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot
Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot
... interactions FEBS Journal 272 (2005) 3531–3541 ª 2005 FEBS 3533 Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations Kristof ... (NAE) wasinvestigated by evaluating the interaction energies and hydrogen positions of the end fragment and the bases of base pair T8 -A2 5 and base G9 (Table 2, Fig. 4).For the bases of the A2 5-T8 ... area of the NAE has been studied by evalu-ating the effect of adenine A2 5, thymine T8, guanine G9 and one water molecule, W57, on the change of the totalenergy. The NGE, has also been examined...
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Báo cáo khoa học: Protein interactions in the sumoylation cascade – lessons from X-ray structures pdf
... proteinscontain an N-terminal SAP domain, an SP-RING domain, a SUMOinteraction motif (SIM) and a C-terminal domain (CTD) [39]. (B) Pc2contains an uncharacterized E3 domain, a ubc9 binding domain and a ... likely that ubc9 and the UFD of uba2 interact at the a1 region. (b) The region below the a1 helix consists mainly of the N-terminal exten-sion of a1 and loops between the b2 and b3 strands and the ... composed of APPBP1 (APPbinding protein 1) and uba3. The domain structures of Aos1 and APPBP1 resemble the N-termini, and those of uba2 and uba3 resemble the C-termini, of the ubiqu-itin E1 enzyme...
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Tài liệu Báo cáo khoa học: Nuclear receptors in the mosquito Aedes aegypti Annotation, hormonal regulation and expression profiling ppt
... fat bodies were collected and RNA lev-els were analyzed using qPCR. Transcript abundance values for AaEcRA, AaEcRB, AaUSP -A, AaUSP-B, AaE7 5A (A) , AaHR3, AaHR4, AaE78,AaHR39, AaHR78 (B) and AabFTZ-F 1A, ... biological repli-cates were analyzed, and Fig. 2 depicts the profilematching both replicates.An increase in transcript abundance for AaEcRA,AaEcRB, AaE7 5A, AaE75B, AaE75C, AaHR3,AaHR4, AaE78 and ... AaERR (D), AaTll, AaPNR-like (E), AaSvp, AaHR38 (F) and the housekeeping genes AaS7 (E) and AaActin (F)are expressed as relative mRNA and are the mean of three independent biological replicates....
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Tài liệu Báo cáo khoa học: Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate docx
... mI,mt2 and mfare m-values associated with each of the identifiable states of the folding pathway and relate to the amount of solvent-exposed surface area in each of these states (see Materials and ... general.Having now established this unequivocally, the above findings are of particular importance in our abil-ity to engineer increased protein–protein interactionstability at will; in particular, ... sur-face area in each of these states, and thus can be used as a measure of the extent to which the folding reaction has pro-gressed. These equations were used to extrapolate the rateconstant and...
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Tài liệu Báo cáo khoa học: Final steps in the catabolism of nicotine Deamination versus demethylation of c-N-methylaminobutyrate doc
... indicat-ed. The presence of AO, SsaDH and CH3-4-aminobutyrate assubstrate were required for maximal activity. In the absence of AOthere was no NADPH produced and with AO, SsaDH and 4-amino-butyrate ... FEBSFinal steps in the catabolism of nicotineDeamination versus demethylation of c-N-methylaminobutyrateCalin-Bogdan Chiribau1, Marius Mihasan1,2, Petra Ganas1, Gabor L. Igloi3, Vlad Artenie2 and ... transaminated to a- ketoglutarate and the remaining succinic semialdehyde may be oxidizedto succinate by a succinic semialdehyde dehydrogenase[16,17]. This pathway for 4-aminobutyrate catabolismis...
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Tài liệu Báo cáo khoa học: Isochore structures in the chicken genome ppt
... contains a large number of gaps (Table 1). In the case of GGA1, there are 9847 gaps remaining. There-fore, applying the segmentation algorithm to each frag-ment will fail to unveil the characteristic ... var-ious intervals of halting parameter values. The Y-axis in the upperpanel shows the cumulative percentage of the values at or beloweach interval. The Y-axis in the lower panel shows the number of sequences ... isochores. Although these are well-known characteristics of isochores of the vertebrateorganisms, the advantage of the technique is that aninvestigator is able to study all of these in a perceiv-able...
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Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... partic-ularly facilitated in the brain, as the brain containslarge quantities of oxidizable lipids and metals, and, moreover, has fewer antioxidant mechanisms thanother tissues [8].Free radicals ... GSH).Pilocarpine-induced SE produces several changes in variables related to the generation and elimination of oxygen free radicals in adult rats [18,30]. An increase in free radical formation is accompanied ... 20 min), and the supernatants used to assay superoxide dismutase and catalase. Superoxide dismutase activity in the pilocar-pine group (n ¼ 8) and control animals (n ¼ 10) wasassayed by using...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... 2-cyclohexen-1-one. The H18 1A and H18 4A enzymes retain activity in reductive and oxidative half-reactions, and thus do not play an essential role in catalysis. Ligand binding and catalysis is not substantially ... bond in close proximity of the N5 atom. A putative flippingmotion of the progesterone molecule along an axisparallel to the FMN plane aligns the C1-C2 with the plane of the isoalloxazine ring and ... (rather than the His-Asn pairseen in OYE, MR and some of the other memberproteins; Fig. 1B) in the active site for ligand and substrate binding. For those members that contain a His-His pair,...
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Tài liệu Báo cáo khoa học: Proteasome involvement in the degradation of the Gq family of Ga subunits pptx
... and the arrowheads indicate the position of Gaq and Ga16. The molecular mass standards areindicated. The arrow indicates the position of some unspecific bands.Proteasome degradation of Gqproteins ... Johansson et al. Proteasome degradation of GqproteinsProteasome involvement in the degradation of the Gqfamily of Ga subunitsBente B. Johansson, Laura Minsaas and Anna M. AragayDepartment ... ormaturation of the protein. An increase was alsoobserved in the rate of degradation of the remainingmutant protein (20% left of the protein) vs. the wildtype (40% left of the protein) at...
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Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... doi:10.1046/j.1432-1033.2003.03658.x(5¢-CCGAGCTCGAGACGTGAAGCGACAATCTCGCAATCT-3¢) containing an XhoI (Promega) site upstream of the start codon and an antisense primer (5¢-CAGCCAAGCTTCTCACTCTTTGATGAAATGCATCT-3¢) con-taining a HindIII ... Takeharu Miyoshi1, Harue Kasuga-Aoki1, Takashi Isobe1, Takeshi Arakawa2,Yasunobu Matsumoto3 and Naotoshi Tsuji11Laboratory of Parasitic Diseases, National Institute of Animal Health, ... similarity against mammalian proteins stored at the current database. The GENETYX-WINTMDNA SequenceAnalysis Software System (Software Inc) and the BLASTnetwork server of the National Center...
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