Báo cáo khoa học: Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO pptx
Báo cáo khoa học: Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO pptx
... specificity of iNOS Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO David ... constantsrelated to the binding of l-Arg [10–14] and NOHA[10], nothing is known about the thermodynamics and kinetics of the binding of guanidines and N-hydroxy- guanidines to iNOS. Removal of the a-amino ... that the binding of BuNOHG to iNOS is favoured slightly over its binding to nNOS. The Kmvalue for the oxidation of BuNOHG by iNOS and nNOS were also found to fol-low the order iNOS < nNOS...
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Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt
... A2 to E153 shouldoccupy 16% of the molecular volume, and thereforeseems too large to represent the lid-like structure at the top of the left view in Fig. 3. We speculate that the loosely structured ... on the opposite side belongs to the C2 domain (141 amino acids) with its extendedloops, whereas the lid-like region at the top representsanother flexible part of the structure. Assuming that the ... the binding of cal-cium ions to the enzyme, and not (or not only) to bet-ter structuring of the substrate aggregates.From both the CD and the activity data, two differ-ent calcium -binding events...
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Báo cáo khoa học: Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates potx
... the potential for their substrate -binding subsites to discriminate between their substrate specificities, aiming to better understand their respective role dur-ing the progression of inflammatory ... of the higher electronegative charge of the Oatom of the Ser side-chain compared to that of the sulfur atom in the Cys side-chain; P3¢ Leu for Probecause a Pro is not well accommodated by the ... by His57 to the west and the aliphaticpart of the Lys40 side-chain to the east [2] (Fig. 1). Asa result, the P1¢ specificity of chymase could bedifferent from that of CG on account of the Lys40...
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Báo cáo khoa học: Piecing together the structure of retroviral integrase, an important target in AIDS therapy pptx
... as no average structure is available). The rmsd between these two structures is 1.2 A˚. The devia-tions between the NMR structures of the isolatedCTD and the crystallographic models of the ... Owing to the symmetry of the complex, the second IBD interacts with the corre-sponding areas of molecules B and A of the CCD. The interactions of the IBD with the CCD in the complexwith the HIV-2 ... to improve the existing models of the structure of IN and of the interactions with the DNA substrates.Structural basis of the enzymaticactivity of IN The CCD of IN is responsible for the two enzymaticactivities...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt
... acids and amino acid deriva-tives have little or no effect on the solvation properties of the substrate and the enzyme active sites or on their thermodynamic activities. Another explanation forthese ... taurine and dimethyl-glycine have not been published elsewhere. We havetherefore measured the thermodynamic parameters of RNase-A in the presence of these amino acids and amino acid derivatives, and ... Tm,DHm and DCpusing the relationship described previously(see equation (2) in [25]).AcknowledgementsFA is grateful to the Department of Science and Technology (India) and the Council of Scientific...
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Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf
... addition of ISP and Qcr10p).On the other hand, in the transition from the 500 kDaband to the 670 kDa band, a structural rearrangement of the bc1complex may occur due to the binding of ISP and ... bind to eachother during the assembly of the bc1complex is alsounknown. Furthermore, as in the case of the biogene-sis of other multi-subunit complexes of the mitochon-drial respiratory ... of the Qcr9p subunitwith the bc1complex precedes the binding of ISP. Infact, the direct absence of ISP (DISP), or the block of its insertion into the bc1complex due to the deletion of the...
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Báo cáo khoa học: Distinguishing between different pathways of bilayer disruption by the related antimicrobial peptides cecropin B, B1 and B3 pptx
... this. Figure 2B,D shows the non-specific binding of CB and CB1 (respectively) to the chipsurface in the absence of liposomes; the level of nonspecific binding between peptides and sensor chip surface ... surfactant Polysorbate 20. The purpose of the surfactant is to reduce sample losscaused by the adsorption of hydrophobic molecules to the surfaces of the flow system of the BIAcore instrument.Peptides ... addition of the peptide, the liposome crum-pled to leave multivesicular and debris-like structures(Fig. 5F–H). The presence of CB1 leads to a propensity to form mutlilamellar vesicles and other...
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Báo cáo khoa học: Correlation between conformational stability of the ternary enzyme–substrate complex and domain closure of 3-phosphoglycerate kinase potx
... requirement of either only one or bothsubstrates in causing domain movement and the ques-tion of whether binding of a single substrate to one of the two domains can also stabilize the structure of the other ... T, and IN and IUare the intercepts and mN and mUare the slopes of the pre- and post-transitional base lines of the raw data, respectively.Quantitative analysis of the experimental dataThermal ... binding are H-bonding and hydrophobic interactions of the adenine ring to bq, and of the ribose ring to the loop between bJ and helix 12, as well as the ionic interaction of the a-phos-phate with...
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Báo cáo khoa học: Relationships between the ethanol utilization (alc ) pathway and unrelated catabolic pathways in Aspergillus nidulans pptx
... induction of alcA while alcR and aldAexpression do not exceed their basal, noninduced levels(results not shown).These data thus show that there is no correlation between the inducing capabilities of ... withour previous data and show that aliphatic and cyclic ketonesdirectly induce the alc genes. There is no correlation between the inductive capacities of ketones and their structurallyrelated ... related to ethylacetate, and the inert ketone 3-pentanone, structurally related to methylpropionate, provided the controls. The structures of theselatter four compounds are shown below. (B) Northern...
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Báo cáo khoa học: A unique tetrameric structure of deer plasma haptoglobin – an evolutionary advantage in the Hp 2-2 phenotype with homogeneous structure pot
... positions and number of Cys residues (total of seven) are com-pletely identical between the two species (the one at the C-terminal region is not shown). Divergence of the amino acids within the species ... did not identify any carbohydratesassociated with the a-chain of either species (data notshown).Hypothetical model for the formation of the deerHp tetramer The ability of the deer Hp to refold ... a- and one b-subunit. The –SH groups that connect the subunits into polymers are located at the edge of the surface. The hindrance between the –SH binding sites A and B prevents forma-tion of...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)TÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ