Báo cáo khoa học: Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins docx

... analysis of macromolecularstructures. J Mol Graph 14, 51–55.K. Ozawa et al. Translational incorporation of DOPA into proteins FEBS Journal 272 (2005) 3162–3171 ª 2005 FEBS 3171 Translational incorporation ... high-level incorporation of l-3,4-dihydroxyphenylalanine (DOPA) into proteins by replacing tyrosine with DOPA in the reactionmixtures. ESI-MS showed speciﬁc incorporation of DOPA in place of tyro-sine. ... production of proteins. Of four proteins produced in soluble form in the presence of tyrosine, two resulted in insoluble aggregates in the presence of high levels of DOPA. DOPA has been found in human proteins, ...

Báo cáo khoa học: Co-incorporation of Ab40 and Ab42 to form mixed pre-ﬁbrillar aggregates ppt

... Department of Medical Biophysics, and2Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering,Department of Biochemistry, University of Toronto, ... constituents of cerebrospinal fluid[5–8]. Both forms are capable of assembling into 60–100 A˚diameter b-sheet fibrils, which form the core of the aforementioned senile plaques.An impressive body of evidence ... ease of formation of mixed vs. homogenousspecies.We believe that the approach of studying fibrillogenesis inthe context of Ab40 and Ab42 mixtures is advantageous.Studies are usually of either...

Tài liệu Báo cáo khoa học: The occurrence of hemocyanin in Hexapoda docx

... presence of hemocyanin in abroad range of ametabolous and hemimetabolous hexapod taxa. Weobtained a total of 12 full-length and 5 partial cDNA sequences of hemo-cyanins from representatives of Collembola, ... tracheal system of Collembo-la, with special reference to that of Sminthurus viridis,Lubb. Q J Microsc Sci 71, 15–30.39 Williams CB (1913) A summary of the present knowl-edge of the Protura. ... occurrence of hemocyanin in HexapodaChristian Pick, Marco Schneuer and Thorsten BurmesterInstitute of Zoology and Zoological Museum, University of Hamburg, GermanyHemocyanins are respiratory proteins...

Tài liệu Báo cáo khoa học: Subproteomics analysis of Ca2+-binding proteins demonstrates decreased calsequestrin expression in dystrophic mouse skeletal muscle pdf

... viscosity of t he extract as a result of D NA, 2 lLofDNase I (200 units) was added per 100 lL of buffer [30].Following filtration through two layers of miracloth a nd theaddition of four volumes of ... ypothesis of muscular dystrophy [20–22]. Deficiency in the D p427isoform o f d ystrophin r esults in the r eduction of a specificsubset of sarcolemmal glycoproteins [23,24]. The lack of the s ... analysis of Fig. 3 and the 1D i mmunoblotting of Fig. 4.As the full-length Dp427 isoform of dystrophin does notenter the second dimension of conventional 2D gels, theexpression level of a-dystroglycan...

Tài liệu Báo cáo khoa học: "Deterministic Parsing of Syntactic Non-fluencies" docx

... understanding of the differences in the kinds of non-fluencies that occur, we are left with a kind of grab bag of grammatical deviation that can never be analyzed except by some sort of general ... Rule-governed System In this paper I present a system of rules for resolving the non-fluencies of speech, implemented as part of a computational model of syntactic processing. The essential idea is ... signal (specifically, a markedly abrupt cut-off of the speech signal) always marks the site where self-correction takes place. Of course, finding the site of a self-correction is only half the problem;...

Báo cáo khoa học: Ten years of predictions…and counting docx

... experi-mental communities that the prediction of the structure of proteins non-evolutionarily related to proteins of known structure is not completely out of reach. Indeed,fold recognition methods ... organizers collect sequences of ‘targets’ i.e. of pro-teins, the structure of which are likely to be solved withina few weeks. These sequences are made available to thecommunity of computational biologists ... more recently, methods able toassemble fragments of proteins of known structure toconstruct the structure of proteins the architecture of Keywordsautomatic prediction servers; CASP; modelevaluation;...

Báo cáo khoa học: "Strong Lexicalization of Tree Adjoining Grammars" docx

... guessedfor distinct (occurrences of) productions are trans-ported to distinct (occurrences of) terminal produc-tions [cf. Section 3 of (Potthoff and Thomas, 1993)and page 346 of (Hoogeboom and ten Pas, ... argumentation).Instead of taking the lexicographically smallestelement of posN(r) or pos∆(r) in the previousproof, we can take any fixed element of that set. Inthe definition of Pwe can change ... lexicalized grammars offersignificant parsing benefits (Schabes et al., 1988)as the number of applications of productions (i.e.,derivation steps) is clearly bounded by the length of the input string....

Báo cáo khoa học: "A Model of Early Syntactic Development" docx

... mean length of utterance as a function of the number of sample sentences (taken in groups of five) seen by the program, b As one would expect, the system starts with an average of around one ... program that attempted to explain some of the basic phenomena of first language acquisition. This system began by learning the meanings of words in terms of a conceptual dependency representation. ... produce it. Of course, this strategy sometimes led to errors in comprehension. Coupled with the disapproval of a tutor, such errors were one of the major spurs to the learning of word orders....

Báo cáo khoa học: "COMPUTATIONAL COMPLEXITY OF CURRENT GPSG THEORY" docx

... result of the application of that metarule. This maximal set is called the finite closure (FC) of a set R of lexical ID rules under a set M of metarules. The cleanest possible complexity proof ... finite closure of a set of metarules M on a set of ID rules R. The category membership problem is to determine if a category or C or a legal extension of C is in the set K of all categories ... exponentially: from I Gi to O(] G [2~). Given a set of ID rules R of symbol size n, and a set M of m metarule, each of size p, the symbol size of FC(M,R) is O(n z~) = O(IGIZ~). Each met~ule...

Báo cáo khoa học: "Controlled Authoring of Biological Experiment Reports" docx

... formidable task remains of understand-ing the function of proteins encoded by genes. For thisreason, the production of recombinant proteins hasbecome an essential aspect of biomedical and biotech-nology ... sequences of DNA molecules and are the tem-plates from which proteins are synthesized. Proteins are long linear molecules, which fold into awell-defined 3-dimensional structure. The structure of a ... the formulation of well-formed semantic representation and of its textual re-alization. Both GF and MDA stress the importance of a formal specification of the well-fbrmedness of thesemantic...

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