... al. (Eur. J. Biochem. 271) Ó FEBS 2004 Solution structure of 2¢,5¢ d(G4C4) Relevance to topological restrictions and nature’s choice of phosphodiester links Bernard J. Premraj1, Swaminathan ... relating to the optimization of t opological features might have been afactor in the rejection of 2¢,5¢ links in preferenc e to 3¢,5¢ link s.Keywords: structure of 2¢,5¢ DNA; evolution of 3¢,5¢ ... 3¢,5¢ vs. 2¢,5¢ links in nucleic acids; AB hybrid structure ; restrained basepair movements; topological restrictions in 2¢,5¢ DNA. Nature’s selection of 3 ¢,5¢ linkages ( instead of 2¢,5¢ linkages)in...