Báo cáo khoa học: Effect of valine 106 on structure–function relation of cytosolic human thymidine kinase Kinetic properties and oligomerization pattern of nine substitution mutants of V106 ppt
Báo cáo khoa học: Effect of valine 106 on structure–function relation of cytosolic human thymidine kinase Kinetic properties and oligomerization pattern of nine substitution mutants of V106 ppt
... Effect of valine 106 on structure–function relation of cytosolic human thymidine kinase Kinetic properties and oligomerization pattern of nine substitution mutants of V106 Hanne Frederiksen*†, ... nine mutations: V106A, V106G, V106H, V106I, V106K, V106L,V106M, V106Q and V106T. We then characterized theenzymatic properties of the mutant enzymes.Theapparentnativesizesofthe–ATPformsofV106WT and ... Dimeric enzymes: V106WT, V106A, V106I and V106T; (B) tetrameric enzymes: V106G, V106H, V106K, V106L,V106M and V106Q. v is the initial velocity.Ó FEBS 2004 Effect of amino acid 106 on human TK1 (Eur....
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Báo cáo khoa học: " Effect of the medical emergency team on long-term mortality following major surgery"
... linezolid and glycopeptides only, and Stenotropho-monas maltophilia, sensitive to ofloxacin only. Polymicrobialwound contamination also included contamination with fungi(for instance, Candida ... Near-drowninginvolved the aspiration of immersion fluids, marine and soildebris into the respiratory tract and all patients displayed signs of pneumonitis and pneumonia upon arrival. Three patientspresented ... (29%), and head (18%). Two-thirds of patients had combined injuriesto the thorax (for instance, pneumo-/hemopneumothorax),including intrapulmonary contusions and lesioning, and frac-tures of the...
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Báo cáo khoa học: "Effect of intern’s consecutive work hours on safety, medical education and professionalism"
... attentional failures after they had been working formore than 16 hours on the traditional schedule [2].Letter Effect of intern’s consecutive work hours on safety, medicaleducation and professionalismChristopher ... hours or more consecutive workare unsafe. Efforts to reduce work hours should focus first and foremost not on the frequency of extended-duration workshifts, but on the duration of consecutive work ... interventions on the performance of upper-levelresidents and other medical staff across a variety of disciplines. We likewise agree that optimizing patient hand-offs, medical education, and trainees’...
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Tài liệu Báo cáo khoa học: Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efficacy pdf
... Characterization of siRNA–TRBP complexformation after TRBP knockdown.Fig. S4. Additional characterization of Dicer and TRBP complexes.Fig. S5. Effect of a terminal mismatch at the guidestrand 5¢ end on ... impact of silencingTRBP and Dicer on the function of the fully paired and mismatched sequences, we wished to examineFig. 1. Effect of guide strand 5¢ end mismatch on silencing efficacy of siRNAs. ... mRNA or a non-targeting (NT) siRNA at a final concentration of 10 nM. Fluorescence was measured 24 h aftertransfection. The mean and standard deviation are shown for each condition. Asterisks...
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Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx
... whether theP-loop moves upon oxidation of the catalytic cysteine isthe ability of the conserved active site arginine to move Effect of ionic strength and oxidation on PhyAsr R. J. Gruninger ... absence of ligand, the WPD loop of PTP1B and RPTPa adoptsan open (inactive) conformation, and upon ligand bind-ing, it adopts a closed (active) conformation (Fig. 3A).In oxidized PTP1B [12,13] and ... of InsP6to PhyAsr (Table 1). Given the absence of structural changes as a function of ionic strength and ligand binding, the effect of ionic strength on catalyticactivity is probably not of...
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Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx
... role of this region in the transcription of theIg-b gene. Deletion of region III decreased the expres-sion of Ig-b mRNA to 40% of the expression in prede-letion cells (Fig. 4A). Region III ... hybridization. Position of the probes, the size and position of restriction fragments hybridizable with the probe, and exon ⁄ introns areshown as in Fig. 2A. Positions of the DT40 specific-DHSs and ... estab-lishment and maintenance of acetylation in the GHlocus. Because deletion of this region has no effect on the formation of cell type-specific DHSs, the regionrequired for H3 and H4 acetylation does...
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Tài liệu Báo cáo khoa học: Effect of gadolinium on the ryanodine receptor/ sarcoplasmic reticulum calcium release channel of skeletal muscle docx
... several cytoplasmic ligands. It is activa-ted by millimolar concentrations of ATP and micromo-lar Ca2+, and inhibited by higher concentrations(> 100 lm)ofCa2+ and by millimolar Mg2+. ... pore [10]. Results about the effect of theluminal (trans) calcium on the activity of the RyR1 arecontroversial depending on experimental conditions.Inhibition of the channel was described ... al. and Herrmann-Franket al. have found activation of the channel at100–250 lm and inactivation at higher luminal calciumconcentrations [15,16]. As the effect of the luminal cal-cium concentration...
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Tài liệu Báo cáo khoa học: Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites pdf
... hydrolysis of the substrates harboring these mutations was morepronounced for the wild-type enzyme and nonactive-site mutants (L90M and M46L) than for the active-site mutants. Consequently, mutation of ... constant showed a strongcorrelation with the volume of the P1¢ residue (correlationcoefficient R ¼ 0.90) and the number of hydrophobiccontacts the side chain formed with residues of the S1¢subsite ... by amino-acid analysis.Construction and purification of HIV-1 PR mutants HIV-1 PR (HIVHXB2CG) having stabilizing substitutions(Q7K, L33I, L63I, C67A and C95A) was cloned into a pETvector, expressed...
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Tài liệu Báo cáo khoa học: "Effect of Cross-Language IR in Bilingual Lexicon Acquisition from Comparable Corpora" pot
... termcorrespondences are estimated, in terms of both computational complexity and the performance of precise estimation of bilingual term correspondences.1 IntroductionTranslation knowledge acquisition ... situ-ation. One limitation of the corpus-based trans-lation knowledge acquisition approach is that thetechniques of translation knowledge acquisitionheavily rely on availability of parallel/comparativecorpora. ... expressions, and collocational expressionsfrom the collection of bilingual news articles on WWW news sites (Utsuro and others, 2002).Figure 1 illustrates the overview of our frame-work of translation...
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Báo cáo khoa học: Effect of flanking bases on quadruplex stability and Watson–Crick duplex competition pptx
... excitation and 520 nm emission filters. Thewells were loaded with solutions of a fixed concentration of preformed quadruplex (50 nm) and increasing concentra-tions of complementary strand (0–1 ... is composed of quartets and interspersed loops, in the genome it is also flanked on each side bynumerous bases. The effect of loop length and composition on quadruplexconformation and stability ... the effect of flanking bases on quadruplex stability and Watson–Crick duplexcompetition has not been addressed. We have studied in detail the effect of flanking bases on quadruplex stability and on...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát hiện xâm nhập dựa trên thuật toán k meansĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Sở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ