Báo cáo khoa học: Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate potx
Báo cáo khoa học: Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate potx
... and/or inhibition (diagram not shown). Inhibition of substrate hydrolysis by substrate analogueTo get additional information on inhibition by excess substrate, we analyzed the inhibition of substrate ... observed inhibition of the decarbamoy-lation rate by high concentrations of substrate analogue(Fig. 3). The existence of another mechanism for substrate inhibition has been proposed by the group of ... 0.05c–aAcceleration of deacetylation by substrate and substrate ana-logue.bAcceleration of decarbamoylation by substrate analogue.Acceleration of deacetylation and decarbamoylation by substrate analogue...
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Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx
... a molecular model of the methyltetra-hydrofolate-binding domain of the rat liver MetS wasconstructed. In the absence of a high- resolution struc-ture of the methyltetrahydrofolate-binding site ... cycle of cytochromeP450 [29]. Details of the potential binding and electrontransfer events that may account for the uncompetitive inhibition of MetS by nitrobenzothiadiazole 2b are thesubject of ... homo-cysteine, with detectable inhibition noted mainly at high concentrations of the inhibitors (0.5 and 1 mm;Fig. 3A).The results of these studies suggest that the two clas-ses of substituted benzo-fused...
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Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
... situation.Dimerization of C-LytAThe occupation of high- affinity binding sites by cholinetriggers the dimerization of C-LytA [21]. The effect of bicyclic amines on C-LytA oligomerization was ana-lyzed by size-exclusion ... lysis) of the cell wall is an essentialprocess for both cell viability and liberation of viru-lence factors. Inhibition of autolysis by excess cho-line might, in the first instance, seem to be of therapeutic ... activity of the enzyme in a competitiveway. Interestingly, both atropine and ipratropium alsoshowed the same kind of competitive inhibition, although with a higher affinity (inhibition constants of 14.3,...
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Tài liệu Báo cáo khoa học: Inhibition of pea ferredoxin–NADP(H) reductase by Zn-ferrocyanide docx
... altered by the presence of the inhibitor, and disrupting the electrontransfer between the flavin and the second substrate mainlycauses enzyme inhibition by Zn-ferrocyanide.Effect of Fld on the inhibition ... Trippi, V.S. (2000) Inhibition of wheat nitrate reductase a ctivity by zinc. B iol. Plant. 43 , 257–262.21. Egash ira, T., Takayama, F . & Sakai, K. (2003) Inhibition by Zn(2+) of A-form monoamine ... binding. Biochimie 80 , 813–820.Ó FEBS 2004 Inhibition of FNR by Zn-ferrocyanide (Eur. J. Biochem. 271) 4593 Inhibition of pea ferredoxin–NADP(H) reductase by Zn-ferrocyanideDaniela L. Catalano Dupuy,...
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Tài liệu Báo cáo khoa học: Inhibition of glyceraldehyde-3-phosphate dehydrogenase by peptide and protein peroxides generated by singlet oxygen attack docx
... thatfivefold higher concentrations of H2O2needed to beemployed to generate a similar r ate and extent of inhibition (Fig. 4 B). Inhibition by protein-derived peroxides wasslower than that induced by ... inactivation of G APDH being metal-ion independent, whereas inhibition of GR and LDH by H2O2occurs most rapidly in the presence of metal ions.It is proposed that the inhibition of GAPDH and GR by these1O2-generated ... Fe2+–EDTA. In contrast, rapid inhibition of GR by H2O2was only observed in the presence of Fe2+–EDTA(Table 1). LDH was not inhibited by the highest concen-trations of peptide and protein peroxides...
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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
... level of p-Akt was increased inPrPC-transfected cells. Inhibition of PrPCexpression by RNA interferenceresulted in decreased p-Akt expression. Inhibition of the PI3K/Akt path-way by one of ... in gastric cancer is associatedwith activation of the PI3K/Akt pathway. Inhibition of PI3K/Akt by LY2940002 or Akt siRNA leads to inhibition of PrPC-induced drug resis-tance and P-gp upregulation ... transcriptionalactivation of P-gp in PrPC-transfected gastric cancercells, inhibition of which would reverse gastric cancerMDR, partly by decreasing the transcriptional activa-tion of P-gp. This model of a PrPC/PI3K/P-gp...
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Báo cáo khoa học: Inhibition of an iron-responsive element/iron regulatory protein-1 complex by ATP binding and hydrolysis docx
... thepresence of IRE, we measured hydrolysis of [32P]ATP[cP] in the presence of 0–400 ng of IRE(Fig. 8). Compared to the amount of ATP hydrolyzedwith 400 ng of IRP alone, addition of IRE increasedthe ... binding of IRP-1to IRE, or instead facilitates dissociation of the com-plex. Enhancement of ATP hydrolysis by IRE in thepresence of IRP-1, but absence of hydrolysis in thepresence of IRE alone, ... Pathobiology, University of Toronto, CanadaMechanisms of post-transcriptional regulation of geneexpression include control of initiation of translationand regulation of mRNA degradation. Among...
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Báo cáo khoa học: ` Inhibition of human ether a go-go potassium channels by 2+ Ca ⁄calmodulin binding to the cytosolic N- and C-termini potx
... in steps of 3) and C-terminal (amino-acids480–962 in steps of 3 and amino-acids 645–895 in steps of 2) cytosolic domains of hEAG1. Binding of BODIPY FL-labeled hCaM in the presence of 25 lmfree ... the C-terminal domain of Ca2+-free CaM,i.e. apoCaM. The activation of these channels is medi-ated by conformational changes in the CaM ⁄ SK2 com-plex induced by binding of at least one Ca2+ion ... mechanism of CaM-mediated closure of hEAG1channels is far from understood mainly because of thelack of structural information on the cytosolic channeldomains in complex with CaM. Initiated by the...
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Báo cáo khoa học: Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives pdf
... or by activity in the C-terminaldomain of the full-size protein, thereby accounting forthe inhibition by ‘acarbose’ reported previously [28].Our previous studies of the inhibitory effect of ... treatment of Type 2 diabetes [23]. Inorder to examine the mechanism of action of thisclass of inhibitors, 3, 5, the stereoisomers of salacinol6, 7 [25], and the six-membered ring analogues of salacinol ... reported Ki of 15 nm [33].However the method of action of acarbose is quitecomplex and it appears to be acting as a type of sui-cide inhibitor of a-amylase in a mechanism wherebythe acarbose...
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Báo cáo khoa học: Inhibition of the NF-jB transcriptional activity by protein kinase A pot
... assayTransient transfection of Jurkat T-lymphocytes wasaccomplished by using 5 lL of SuperFect transfectionreagent (Qiagen) per ml of culture medium and a total of 1 lg of plasmid DNA. Blank control ... subunit of NF-jB,andmeasured the level of NF-jB-dependent luciferase geneexpression. Transfection of p65 alone resulted in high levels of luciferase expression, whereas cotransfection of p65 ... DNA-binding of NF-jB (Fig. 3D).Thus, it is likely that the inhibitory effect of PKA on NF-jBis not due to the inhibition of DNA-binding activity of NF-jB.PKA impairs transactivation potential of p65p65...
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