... with indinavir (Eur. J. Biochem. 271) 1519inhibitor. Thus, subtle conformational changes of residuesinteracting with the inhibitor play a role in the kinetics.The number of protease–indinavir ... interactionswith indinavir. In contrast, PRL90Mshowed fewer van derWaals contacts with indinavir, the main chain atoms ofresidues 80–82 were further from the indinavir, and the sidechain ... with indinavir, of 3.8 A˚ .In PRV82A, the change in the position of the main chainatoms placed the Cb atom of Ala82 within reasonable vander Waals distance of indinavir (4.1 A˚), resulting...