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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx

Báo cáo khoa học: Human telomeric G-quadruplex: structures of DNA and RNA sequences ppt

Báo cáo khoa học: Human telomeric G-quadruplex: structures of DNA and RNA sequences ppt

... formed between the 3¢-end of each block; and (c) 5¢-to-3¢, in which the stacking interface isformed between the 5¢-end of one block and the 3¢-end of the other. In the ‘same-direction stacking’ ... the ends of the G-tetrad core, (b) groove binding, (c)taking place of one or more strands in the core, (d)interacting with the backbone (core and loops), and (e)interacting with the loop bases. ... three G-tracts of one strand and only the 3¢-end G -tract of the other strand [30] (Fig. 3D). The core of this structure, called the (3 + 1) core, hasthree strands oriented in one direction and one...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx

Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx

... proteins they probably formpart of the copper binding sites in this protein.Although there are four histidines in the C-terminal,another histidine is present at position 18, and given the folded ... withglycine alone was performed and no binding was observed. In our hands, as others [54], the most reproducible datawas obtained from injections of the metal into a solution of the protein. Typically ... high affinitycopper binding protein, and (b) that amyloid fibrilformation of this protein is diminished in presence of Cu2+ions. Another interesting finding is thatcopper binding gets less strong...
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Tài liệu Báo cáo khoa học: Molecular cloning, recombinant expression and IgE-binding epitope of x-5 gliadin, a major allergen in wheat-dependent exercise-induced anaphylaxis ppt

Tài liệu Báo cáo khoa học: Molecular cloning, recombinant expression and IgE-binding epitope of x-5 gliadin, a major allergen in wheat-dependent exercise-induced anaphylaxis ppt

... recombinant x-5 gliadin protein thatcan be used for diagnosis and possibly treatment of WDEIA.ResultsIdentification of IgE-binding epitopes in x-5 gliadin The IgE-binding epitopes of x-5 gliadin ... in x-5a gene in Fig. 2, includes all of the detected IgE-binding epitope sequences. Afteramplification of the DNA encoding this half of the x-5a gliadin protein by PCR, the DNA fragment wasinserted ... contains two stop codonsindicating that x-5b is pseudogene. The C-terminal half (178 amino acids) of the x-5a gliadin protein, including all 11 IgE-binding epitope sequences,was expressed in...
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Báo cáo khoa học: PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL pot

Báo cáo khoa học: PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL pot

... targets of PRDM1 repression.These include genes required for maintaining the B-cellphenotype and in maintaining cellular proliferation, for example, CIITA, PAX5, Spi-B, Id3 and c-myc [42–46]. In ... site of PRDM1 binding. The data are presented as percent input and the error bars represent the SEM of three independent experiments. P-values are indicated. Expression of PRDM1 protein in the ... 3B). Similar to the LMO2 results,significant PRDM1 binding was clearly detected at the HGAL promoter in the region of the predictedPRDM1 binding sites. The intensity of binding wasapproximately...
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Báo cáo khoa học: High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease pdf

Báo cáo khoa học: High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease pdf

... heparin as a co-factor for inhibition of some of its targets such as thrombin[28]. The co-factor effect of heparin is due to achange in the conformation of the SERPIN as wellas the ability of ... heparin and N-acetyl heparin promotean increase in FSAP activity rather than inhibitingit. Thus, polyanion binding to SERPINs, over and above their binding to FSAP, plays a decisive role in mediating ... amplified by heparin. To furtherinvestigate the structural requirements of polyanions for controlling FSAPactivity, we performed binding, activation and inhibition studies using hep-arin and derivatives...
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Báo cáo khoa học: High resolution structure and catalysis of O-acetylserine sulfhydrylase isozyme B from Escherichia coli pot

Báo cáo khoa học: High resolution structure and catalysis of O-acetylserine sulfhydrylase isozyme B from Escherichia coli pot

... peaks. Of these, the loops at peak positions 94, 116, 132, 202 and 215 form the lips of the mouth of the active center pocket(Fig. 1) and are therefore important for catalysis. The other peaks ... mutants and determined their catalyticactivity using TNB as the nucleophile. TNB seems tobe most appropriate for guiding enzyme engineeringintended for the synthesis of compounds of similarsize. ... thanhydrogen sulfide, and is therefore a promising candi-date for the production of novel b-substitutedl-amino acids as building blocks for the synthesis of pharmaceuticals and agrochemicals [7–9].Keywordsbiosynthesis...
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Báo cáo khoa học: Stage specific expression of poly(malic acid)-affiliated genes in the life cycle of Physarum polycephalum Spherulin 3b and polymalatase potx

Báo cáo khoa học: Stage specific expression of poly(malic acid)-affiliated genes in the life cycle of Physarum polycephalum Spherulin 3b and polymalatase potx

... bc-crystallin fold. The residues shown in grey indicate the side chains and backbone sites thatare involved in calcium binding [24]. The residues in the conserved tyrosine corners are in bold [24]. ... domain folds, spheru-lin 3a and NKA48 contain only a single domain fold. The stability of these two proteins is highly dependenton calcium binding [25]. The typical domain motivescontain a ... approximately40 amino acid residues) pair to form a domain. The domain fold contains a pair of calcium binding sites.While the bc-crystallins of lens (not shown) and lowerorganisms in Fig. 2 contain two...
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Tài liệu Báo cáo khoa học: Loose interaction between glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase revealed by fluorescence resonance energy transfer–fluorescence lifetime imaging microscopy in living cells doc

Tài liệu Báo cáo khoa học: Loose interaction between glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase revealed by fluorescence resonance energy transfer–fluorescence lifetime imaging microscopy in living cells doc

... upon the distance between and relative ori-entation of two fluorophores, being independent of the strength of protein–protein interactions. In the case of very weak interactions as described in ... that induction of FRET does not sim-ply depend on the length of linkers. In the linker con-taining seven amino acids, a Pro-Pro sequence that isnot contained in other linkers is incorporated. ... coexpres-sion of PGK did not affect the lifetimes. Coexpression of citrine–GAPDH and PGK weakly decreased the lifetimes of cerulean–GAPDH in the cytoplasm, con-firming the results shown in Fig. 2B,D. The...
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Tài liệu Báo cáo khoa học: An allosteric DNAzyme with dual RNA-cleaving and DNA-cleaving activities doc

Tài liệu Báo cáo khoa học: An allosteric DNAzyme with dual RNA-cleaving and DNA-cleaving activities doc

... steric interference in the DNA-cleavingcatalytic domain of DRc DNAzyme. Reducing the RSto 6 bp increased the rate of DNA cleavage, whichapproached the self-cleaving rate of DRc DNAzyme in the ... structure and evolution of the DNAzymes. The regulating effects of RS and RNase on the DNA cleavage of DRc DNAzymeAfter characterizing the DNA-cleaving and RNA-cleaving activities of DRc DNAzyme, ... assays, the DNAzymewas first denatured by heating to 90 °C for 2 min, and thenincubated at 0 °C for 5 min. Trace amounts of 5¢-32P-labeledDNAzyme were incubated in reaction buffer A, containing10...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal–thiolate clusters* doc

Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal–thiolate clusters* doc

... located in independent domains(a b-domain for the N-terminal cluster and ana-domain for the C-terminal cluster). In the absence of metals, apo-thionein (apo-T) is predominantly unstruc-tured and ... asa result of the formation of disulfide bridges [2]. Sec-ond, in contrast to the high thermodynamic stability, the binding is kinetically labile, allowing rapid intra-molecular and intermolecular ... partial) for binding to the N-terminal b-domain [4,7].These metal–thiolate cluster structures are unusual for metal-binding proteins and are responsible for the typical reactivity properties of MTs....
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