Báo cáo khoa học: Involvement of NF-jB subunit p65 and retinoic acid receptors, RARa and RXRa, in transcriptional regulation of the human GnRH II gene pot
Báo cáo khoa học: Involvement of NF-jB subunit p65 and retinoic acid receptors, RARa and RXRa, in transcriptional regulation of the human GnRH II gene pot
... vitro and in vivobinding of NF-jB subunit p65 and the retinoic acid receptors, RARa and RXRa, to the promoter sequences. Over-expression of these protein factorsindicated that p65 is a potent ... unliganded RARa and RXRa and retinoic acid (RA) treatments on GnRH II promoteractivityTo investigate the in vivo effect of RARa and RXRon the transcriptional regulation of the hGnRH II gene, the ... the GnRH II gene, has also been reported [6]. The presentstudy aimed to define the cis-acting element and investigate the protein factors involved in regulation of the hGnRH II gene in TE61 and...
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Báo cáo khoa học: Succinate dehydrogenase flavoprotein subunit expression in Saccharomyces cerevisiae – involvement of the mitochondrial FAD transporter, Flx1p ppt
... role in maintaining the normalactivity of mitochondrial FAD-binding enzymes, including lipoamidedehydrogenase and succinate dehydrogenase flavoprotein subunit Sdh1p. Adecrease in the amount of ... of mitochondrial FAD-binding enzymes. Correlation of these has been demonstrated in human pathologies,including deficiencies of the flavoprotein subunit of respiratory chain complex II [30] and in RR-MADD[31,32], ... (FCCP) collapses the membranepotential generated by the respiratory chain and there-fore inhibits import of proteins into the mitochondrion[28]. WT-HA cells were incubated either in the absenceor...
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Tài liệu Báo cáo khoa học: Involvement of two positively charged residues of Chlamydomonas reinhardtii glyceraldehyde-3-phosphate dehydrogenase in the assembly process of a bi-enzyme complex involved in CO2 assimilation doc
... be potentially involved in the interaction with the other partners of the GAPDH–CP12–PRK complex. The model of wild-type GAPDH from C. rein hardtii, like the structure of spinach GAPDH, shows the ... to its role in the catalytic mechanism of GAPDH could be essential for the binding of CP12. The presence of this region at the interface of GAPDH and CP12 could also explain the kinetic changes ... to the binding of PRK. In agreementwith this last hypothesis, our analysis of the k ineticproperties of the GAPDH–CP12 subcomplexes obtainedwith the K128A/E and R197A mutants showed that the kinetic...
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Báo cáo khoa học: Involvement of lysine 1047 in type I collagen-mediated activation of polymorphonuclear neutrophils doc
... members of the ‘lysine–threo-nine–serine (KTS)–disintegrin’ family contain the consensus KTS sequence, rather than RGD, in theirintegrin- binding loop [25,26]. In addition, glycation of collagen ... evaluatesimultaneously the in uence of the e-NH2group charge and the steric hindrance of the side chain. The residuedeprived of a side chain did not disturb the particularstructure of the collagen a chain. ... oxidase-hypoxanthinesystem (data not shown). These results suggested the involvement of lysine-containing sequences in the acti-vation mechanism. Involvement of lysine residues contained withina1CB6...
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Báo cáo khoa học: Involvement of the V2 receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cells pdf
... angiotensin IV and may play a role in the maintenance of memory [19]. In the current study, we detected the P-LAP protein in the kidney and examined its potential role. We have observedthat 8-arginine-vasopressin ... protein in the kidney In our previous work, we examined the expression of P-LAP in various human tissues by Western blot analysis and found that the kidney is one of the major tissuesexpressing the ... in the distal tubules of the cortex and the collecting ducts of the cortex and medulla (data not shown).Vesicular distribution of P-LAP protein in NRK52E cells The subcellular localization of...
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Báo cáo khoa học: Involvement of Ech hydrogenase in energy conservation of Methanosarcina mazei pptx
... molecule, the ratio of ATP syn-thesis and H2production should be in the range of 0.33. The results presented showed rates of 1.5 nmolATPÆmin)1Æmg)1 and 32.8 nmol H2Æmin)1Æmg)1, result-ing ... 2010)doi:10.1111/j.1742-4658.2010.07744.xMethanosarcina mazei belongs to the group of aceticlastic methanogens and converts acetate into the potent greenhouse gases CO2 and CH4. The aceticlastic respiratory chain involved in methane ... synthesisrates observed in the process of methanogenesis frommethyl-S-CoM + H2[15]. In the absence of Fd or CO,H2production was < 0.1 nmolÆmin)1Æmg protein)1(Table 1) and ATP synthesis...
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Tài liệu Báo cáo khoa học: Aldehydes release zinc from proteins. A pathway from oxidative stress⁄lipid peroxidation to cellular functions of zinc pptx
... phos-phorylation signaling and gene expression.ResultsAldehydes release zinc from zinc-binding proteins The effect of aldehydes on the zinc-binding capacity of zinc proteins was assayed by employing spectropho-tometry ... levels of aldehydesaffect zinc metabolism and that zinc release and ensu-ing binding of zinc to other proteins is one aspect of the molecular actions of aldehydes that are generatedduring lipid ... format acidic pH (b-hydroxyacrolein). The following investigations focus on the effects of acetaldehyde and acrolein because of the relevance of these aldehydes for the biological effects of ingestedethanol...
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Báo cáo khoa học: 15 N-Labelled proteins by cell-free protein synthesis Strategies for high-throughput NMR studies of proteins and protein–ligand complexes doc
... in the case of the C-terminal domain of the s subunit of DNA polymerase III from E. coli, a 16 kDa a-helicalprotein [10].Combinatorial [15N]-labelling depends on suppres-sion of transamination ... by amino acid type, but also by the amino acid type of the residue preceding it in the amino acid sequence. Sequence specific resonance assignments of the [15N]-HSQC peaks are obtained in this ... iden-tify the 15N-labelled amino acids used in the cell-free preparation of the five different samples. The last column displays the averageamino acid abundance in proteins according to the NCBI...
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Báo cáo khoa học: Pulchellin, a highly toxic type 2 ribosome-inactivating protein from Abrus pulchellus Cloning, heterologous expression of A-chain and structural studies ppt
... potent plant toxin, similar to abrin and ricin.Cloning of the coding gene from pulchellin A-chainwill greatly facilitate the understanding of the proteinstructure and function, and lay a solid ... reported for the N-terminus of the abrin-c A-chain, it was possible to define the firstamino acid of the mature PAC. Comparing the amino acid sequences with that of the abrin-c A-chain precur-sor from ... amino acid sequence of recombinant pulchellin A-chain (rPAC) aligned to abrin-a, abrin-c and ricin (RTA) A-chains. Conservedamino acids are highlighted in gray. rPAC residues involved in the potential...
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Báo cáo khoa học: "A Stacked Sub-Word Model for Joint Chinese Word Segmentation and Part-of-Speech Tagging" potx
... furtherused in POS tagging in (Ng and Low, 2004). Onemain disadvantage of this model is the difficulty in incorporating the whole word information. The second kind of solution is the “word-based”method, ... SegC and SegTagLare the predictions of the three coarse-grained solvers. For the three words at the begin-ning and the two words at the end, the three predic-tors agree with each other. And these five ... an f-score of 94.02 for the whole task, resulting in relative error reductions of 14.1% and 5.5% respectively over the best systemreported in the literature. The remaining part of the paper is...
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