... employingthis approach, close to 70% inhibition of viral infec-tion was achieved in cell lines stably transduced withan expression vector encoding short hairpin RNAagainst the CCR5 receptor. Similarly, ... Bruton’s tyrosine kinase; EBV, Epstein–Barr virus; ITK, inducible T-cell kinase; NKT cell,natural killer T cell; PH, pleckstrin homology; PKB, protein kinase B; R2 8C, arginine 28 mutated to cysteine; ... T-cell kinase (ITK) could in uence the infectivity of HIVand also have anti -in ammatory activity. Since 2006, several patients carry-ing a fusion protein, originating from a translocation joining...