Báo cáo khoa học: Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression pdf
... 2008 FEBS 5551
Pituitary adenylate cyclase-activating polypeptide
attenuates streptozotocin-induced apoptotic death
of RIN-m5F cells through regulation of Bcl-2 family
protein mRNA expression
Satomi ... STZ-induced
apoptotic death of RIN-m5F cells through the regula-
tion of pro -apoptotic proteins. These novel findings,
taken together with...
... common cause of death from can-
cer among Mexican women [21]. Therefore, the aim of
this work was to evaluate the effect of pharmacological
doses of DHEA on the proliferation and death of
three cell ... suggest that the effect
of DHEA upon CASKI cells is more cytotoxic than
cytostatic.
DHEA induces apoptotic and necrotic death
To determine the type of death induced b...
... terminally ill: the ‘risk of unacceptable
badness’
David Crippen
Associate Professor, Director, Neurovascular ICU, Department of Critical Care Medicine, University of Pittsburgh Medical Center, ... maintaining some of the vital
functions of the body, but the same technology does not
necessarily allow us to heal underlying disease processes [2].
An unintended side effect of modern...
... sus-
ceptible cells at multiple levels [62]. In resting human
CD4
+
T cells, the expression of ITK is extremely low
and often undetectable in immunoblot analysis. The
activation of CD4
+
cells, however, ... absence of B lymphocytes
and plasma cells and very low levels of immunoglobu-
lins of all classes. Humoral immune responses are
essentially nonexistent. T cells are not...
... systems
there is compelling evidence for the control of energy
metabolism via the central nervous system (CNS),
notably through the regulation of feeding behavior
and satiety [5,6]. Furthermore, ... entry of fatty acid into mitochon-
dria. Thus, the steady-state level of malonyl-CoA in
these tissues is determined by the relative activities of
ACC and malonyl-CoA decarboxylase.
R...
... abundant proapoptotic protein of the Bcl-2
family that is crucial for death receptor-mediated
apoptosis in many cell systems [16,17]. The BH3
domain-only proteins are a subfamily of the Bcl-2
family ... activity after the treatment of cells with TRAIL
or TRAIL and EGF in control cells, cells expressing
GFP–Itch or cells with reduced Itch expression
(Fig. 3B). The tr...
... the membrane localization of
proteins will facilitate the formation of protein com-
plexes and increase reaction rates [35]. To mimic the
in vivo situation, Src and other proteins can be embed-
ded ... deregulation of
Src signaling in cancer. A central result of our study
reveals that all necessary prerequisites for the diverse,
baroque dynamics of Src responses already exist in t...
... (2001) Characterization of binding of
leukotriene C4 by human multidrug resistance protein
1. Evidence of differential interactions with NH2-and
COOH-proximal halves of the protein. J Biol Chem
276, ... increasing concentrations of an anticancer drug.
The resulting resistant cells expressed high levels of
ABC transporters compared to the minute expression
of these protein...
... common drawback of such approaches
is the cost of the affinity resins used to isolate the
fusion protein and the proteases required to liberate
the protein of interest from the fusion protein. Such
considerations ... human
proteins smaller than about 50 residues is often
hampered by proteolytic degradation of unstructured
proteins ⁄ peptides; therefore small entities are com-
monl...
... this respect, the outcome of
ostreocin-D treatment of CaCo-2 cells remains
unknown.
The impact of palytoxin action on actin filament sys-
tem is not restricted to epithelial cells. In a recent
report, ... natural blocker of the Na
+
pump and an inhibitor of palytoxin action, have pro-
vided interesting findings. Through the partial inhibition
of Na
+
⁄ K
+
-ATPase, and regardle...