... compilation ª 2008 FEBS 3015REVIEW ARTICLEProtein interactions in the sumoylation cascade – lessons from X-ray structuresZhongshu Tang1,*, Christina M. Hecker2,, Astrid Scheschonka1and ... in sumoylation,neddylation and ubiquitination reactions. (A) and (B) are modified from [1], and (C) and (D) from [29] and [7], respectively.Z. Tang et al. Interactions between sumoylation proteinsFEBS ... are conserved from yeast to human [2]. The crystal structures of humanAos1-uba2, human APPBP1-uba3, and of the partlyresolved mouse uba1, are closely related [15,21,23](Fig. 3C). From the side...