Báo cáo khoa học: Functional and structural characterization of novel mutations and genotype–phenotype correlation in 51 phenylalanine hydroxylase deficient families from Southern Italy docx
Báo cáo khoa học: Functional and structural characterization of novel mutations and genotype–phenotype correlation in 51 phenylalanine hydroxylase deficient families from Southern Italy docx
... 2009 FEBS 2059 Functional and structural characterization of novel mutations and genotype–phenotype correlation in 51 phenylalanine hydroxylase deficient families from Southern Italy Aurora Daniele1,2,3, ... severe form of hyperphenylal-aninemia is classic phenylketonuria. We sequenced the entire gene for phenylalanine hydroxylase in 51 unrelated hyperphenylalaninemia patients from Southern Italy. The ... analysis of thePAH gene in 51 unrelated HPA patients from South-ern Italy. In addition to the molecular epidemiology of PAH mutations, we characterized the functional prop-erties of two novel mutations...
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Tài liệu Báo cáo khoa học: Functional interaction between RNA helicase II⁄Gua and ribosomal protein L4 pptx
... activity and GTP-stimu-lated RNA foldase activity [17–19]. The presence of both RNA unwinding and RNA folding activities in two distinct domains of the same protein highly sug-gests a role of Gua in ... is a multifunctional nucleolar protein involved in ribosomal RNA processing in Xenopus laevis oocytes and mammalian cells.Downregulation of Gua using small interfering RNA (siRNA) in HeLacells ... relevance of RPL4 in lower and highereukaryotes. We hypothesize that the function of RPL4is partly regulated by protein–protein interactions.To determine the RPL4 domains involved in Guainteraction,...
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Báo cáo khoa học: Photosynthetic acclimation: Structural reorganisation of light harvesting antenna – role of redox-dependent phosphorylation of major and minor chlorophyll a/b binding proteins pot
... activation of specific thyla-koid-bound kinase(s). This activation involves thebinding of PQH2to the quinol-binding site of the cytb6f complex and initiates the phosphorylation of themobile ... the tip of thePSI core [51, 52]. Arabidopsis plants devoid of the PsaOcore subunit showed 50% reduction in state transitions[52], indicating the role of this protein in putativebinding of mobile ... FEBSMINIREVIEWPhotosynthetic acclimation: Structural reorganisation of light harvesting antenna – role of redox-dependentphosphorylation of major and minor chlorophyll a/bbinding proteinsJoanna...
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Tài liệu Báo cáo khoa học: Interactions between M proteins of Streptococcus pyogenes and glycosaminoglycans promote bacterial adhesion to host cells pdf
... expression of protein H [23], whileBMJ71 is deficient in both protein H and M1 protein [24]. In MC25, the COOH-terminal part of the emm1 gene of AP1 has been deleted resulting in a strain lacking cell ... constructs,spectinomycin (100 lgÆmL)1)wasused.Proteins, GAGs, radiolabelling and binding assayRecombinant protein H, M1 protein and the A-S and S-C3fragments of M1 protein were prepared ... important for binding of DS to M5 expressingbacteria. The loss of binding obtained with M5 lacking boththe B and C regions (M5DBC) could reflect a contribution of both regions in DS-binding, but is...
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Báo cáo khoa học: Amyloid oligomers: spectroscopic characterization of amyloidogenic protein states docx
... twofold:the necessity of a cysteine-scanning approach; and theintrinsic bulkiness and hydrophobicity of the pyrenelabel.Modern fluorescent techniques and novel spectroscopic stainsBy using ... probes and optical spectroscopy are nowentering a phase enabling the in vivo interrogation of the role of oligomers in amyloidosis. Such techniques used in parallel with in vitro experiments, of increasing ... phenomenon by using site-specific labelling of twodifferent Alexa dyes (488 and 647) introduced in anexperimental amyloidogenic protein composed of theSH3 domain of PI3 kinase [42,43]. By mixing theselabelled...
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Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
... thephysical interactions between receptor proteins [51, 52].ResultsRadioligand binding assayAs shown in Table 1, the binding parameters obtainedfor dopamine D1receptor and its mutant indicate ... different pro-teins of interest, Pearson’s correlation coefficients and coefficients of determination were estimated (Fig. 2C). In case of cells co-expressing dopamine D1 and dopa-mine D2receptor ... GavÞ2rð4Þwhere Ri and Gi are the red and green intensities of voxelI, respectively, and Rav and Gav the average values of Ri and Gi, respectively.It is used for describing the correlation of the intensitydistributions...
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Báo cáo khoa học: Stage specific expression of poly(malic acid)-affiliated genes in the life cycle of Physarum polycephalum Spherulin 3b and polymalatase potx
... a domain. Thedomain fold contains a pair of calcium binding sites.While the bc-crystallins of lens (not shown) and lowerorganisms in Fig. 2 contain two domain folds, spheru-lin 3a and NKA48 ... function.bc-Crystallins are two-domain proteins found in vertebrate eye lenses and have distant relatives in microorganisms (e.g. the proteins in Fig. 2). Thebc-crystallin domain of spherulin 3a from P. ... 2006 FEBS in Protein S (7) or spherulin 3a (2). NKA48 (1) dif-fers from all of these proteins by not containing atyrosine in a corresponding position. In contrast toNKA48, spherulin 3a is stabilized...
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Báo cáo khoa học: Human anionic trypsinogen Properties of autocatalytic activation and degradation and implications in pancreatic diseases potx
... 15-kDa band, containing both theN- and C-terminal chains that are identical in size (band A).Activation of double-chain trypsinogen to double-chaintrypsin results in the appearance of band B, ... conversion of trypsinogen to trypsin, as a fainttrypsin band became apparent at 60 min, and moresignificant trypsin generation was detectable by 120 min. In the absence of Ca2+, autoactivation of ... volume.Trypsin activity was expressed as percentage of the initialactivity measured at the beginning of the incubation.SDS/PAGE analysis of trypsinogensAutoactivation and degradation of trypsinogens...
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Báo cáo khoa học: "Diagram Understanding Using Integration of Layout Information and Textual Information" ppt
... as shown in Figure 1 and 2. Taking advantage of this, we propose here a new method for analyzing the PBF diagrams by using natural language information. In the PBF, many kinds of information ... Process of PBF Diagram Understanding 4.1 Representation of Layout Information Layout information is represented by hand in the following way. Step 1. give ID number to all words and sketches in ... using many kinds of clue expressions in the PBF explanation texts. 3 Information for PBF Diagram Understanding 3.1 Layout Information For analyzing the PBF diagrams, we utilize two kinds...
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Báo cáo khoa học: Cytokinin-induced structural adaptability of a Lupinus luteus PR-10 protein potx
... in thehydrophobic cavity of the protein and a degree of conformational changesaccompanying ligand binding. The structural adaptability of LlPR-10.2B and its ability to bind different cytokinins ... University of Lodz, Poland3 Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw, Poland4 Institute of Plant Genetics, Polish Academy of Sciences, Poznan, Poland5 ... cytokinins, with one example of isopentenyl (trans-zeatin) and one of furfuryl (kinetin)N6-substituted adenine.The three crystal structures of PR-10-type proteinscomplexed with cytokinins,...
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