... cloning, expression and function in tumor progression and metastasis. Nat Med 5, 793–802.23 Ilan N, Elkin M & Vlodavsky I (2006) Regulation, function and clinical significance of heparanase in ... al. New concepts for heparanase function FEBS Journal 277 (2010) 3890–3903 ª 2010 The Authors Journal compilation ª 2010 FEBS 3903MINIREVIEW Proteoglycans in health and disease: new concepts for heparanase ... [23,25,30,31] and are not discussed in detail here. Heparanase in tumor progression and metastasis Enzymatic activity capable of cleaving glucuronidiclinkages and releasing polysaccharide chains resistantto...