... 3986–3998 ª 2010 The Authors Journal compilation ª 2010 FEBS Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r Structural biology Andra´sLa´ng1,*, ... timescale in both of the free modules. Thus, these loops are strong candidates for binding sites of other complement and ⁄ or regulatory proteins. The large insertion between E and F strands in C1r ... complement control protein; CCP1, first complement control protein module of C1r; CCP2, second complement control protein module of C1r; CCP1CCP2, tandem of the two CCPs from C1r; CCP1single,single...