... recognizes the duplex ratherthan the component single strands. An additionaladvantage to modifying the backbone chemistry of the sense strand is that by impairing the incorporation of this strand into ... [13,14]. OAS1 is activated by binding to dsRNA and induces sequence-independent degrada-tion of viral and cellular single-stranded RNA(ssRNA) by activating RNaseL [15]. OAS1 also playsan important ... (2009) The promises and pit-falls of RNA-interference-based therapeutics. Nature457, 426–433.5 Kleinman ME, Yamada K, Takeda A, ChandrasekaranV, Nozaki M, Baffi JZ, Albuquerque RJ, Yamasaki S,Itaya...