... experi-
ments. Therefore, this study demonstrates that BIAcore
analysis is an excellent technique for the assessment of
relative binding af®nities of IGF analogues and IGF-I for
the IGF1R.
The IGF1R-binding ... determined at a ¯ow
rate of 30 lLámin
)1
to minimize mass transfer effects, and
by allowing 300 s for association and 900 s for dissociation.
In the case o...
... 1B shows the pattern
seen after the development of the blot. With increase
in time of incubation, the intensity of the band for the
monomeric protein decreased, whereas the bands for
the higher ... the presence of the neurotoxin, there was a
delay in the lag time for fibrillation. The lag time
increased from 74.9 h in case of a -synuclein alone to
86.8...
... characterized
by the degeneration of larval tissues, such as the velum
and the foot, and the remodelling of larval tissues to
produce adult tissues (i.e. the development of the gills
and the production of ... sequence of about 90 amino acids of
unknown function. The high degree of identity of the
Cg-Clp1 and Cg-Clp2 Glyco_18 domains (84% iden-
tity) a...
... in the
affinity for GDP of Ga and the subsequent substitu-
tion of GDP by GTP [10]. Such an agonist-dependent
decrease in the affinity for GDP can be detected as the
increase in binding of the ... are
the a2 helix, the b6 ⁄ a5 loop, the a5 helix and the
N- and C- extreme termini [31]. In addition, the a4
helix and a4 ⁄ b6 loop region of Ga
i1
are importan...
... mutants are indicated in the box on the top right. The scale
for the velocity of the mutants is indicated on the left side and that
for the wild-type enzyme on the right side. The assay conditions ... carboxybiotin. The model shows the approximate
location of important residues of helix IV, helix VIII and of region IIIa of the b subunit. Also shown is...
... into the nature of interaction between the
rMP and NV was obtained by monitoring the effect of
pH and NaCl concentration (Fig. 5B,C). The forma-
tion of salt bridges and hydrogen bonds crucial for
protein–protein ... of viruses from other gen-
era. Within sobemoviruses, the sequence of the SeMV
MP was closest to that of the SBMV-Ark MP (32%
sequence identity)...
... values
and rates of events (adjusted for total ICU admissions) in the
12-month periods before and after the commencement of the
MET service.
The difference in the incidence and hospital mortality for
adverse ... response to the '5 Million Lives campaign' pro-
moted by the Institute of Health Improvement (IHI) [11]. On the
other hand, the degree of...
... or treated for
urinary symptoms (OAB, LUTS and/ or BPH). Fur-
thermore, those with OAB had a worse quality of life
score. Mean quality of life score for those with OAB
was 3.4 of 6, and those ... quality of
life score. Mean quality of life score for those with
OAB was 3.4 of 6, and those without OAB 1.6. Fur-
thermore, 59% reported urge incontinence, 76% ur-
gency,...
... loss of other actors in the migra-
tion process, such as members of the doublecortin
family Dcx and Dclk [146–148].
Conclusions
The emerging landscape of the role of HSFs in devel-
opment is the ... controls the number of radial glia cells and
fibers and the number of Cajal–Retzius cells. Thus,
the later defect results in disturbances of the Reelin
cascade...