... Guion-Almeida ML and Richieri-Costa A. Frontonasal dysplasia, macroblepharon, eyelid colobomas, ear anomalies, macrostomia, mental retardation, and CNS structural anomalies: Defining the phenotype. ... Guion-Almeida ML and Richieri-Costa A. Frontonasal dysplasia, macroblepharon, eyelid colobomas, ear anomalies, macrostomia, mental retardation, and CNS structural anomalies. A new syndrome? Clin ... nervous system damage, mental status is usually normal, and only occasionally learning disabilities, behavioral and/ or language problems can present [20]. Image studies reveal in all cases basal...