... Additionally, the greatest derepression that we observed was in the con-text of the GBD fusion proteins, which contain annuclear localization signal within the GBD part of the protein. Another ... inhibit the ability of the full-length proteinsto activate transcription. In the case of Meis2, the C-terminus contains a strong transcriptional activationdomain (AD), the activity of which ... independently of Pbx, and does notpossess the autoinhibitory function of the Hth domain.In summary, our data suggest that one function of the conserved Hth domain is to inhibit the activity of the transcriptional...