... are linked to accessory proteins (e.g. zonulaoccludens proteins and cingulin), forging a connectionto the actin cytoskeletons of endothelial cells [8]. Occlu-din is an 65 kDa phosphoprotein ... as insulin, trans-ferrin and leptin, to cross the BBB [13].Molecular basis of brain angiogenesis and barriergenesisHypoxia and the hypoxia-inducible factor systemAs an embryo develops and its ... signaling pathways involved in pathfinding,growth, migration and differentiation. In fact, a num-ber of factors known in CNS development, includingaxon guidance molecules and neurotrophins,...