Báo cáo khoa học: "Rigid Grammars in the Associative-Commutative Lambek Calculus are not Learnable" pptx

... to the types found in G,), therefore c HaVaa) must be in Tree,. All the other types found in this tree mustbe introduced by hypotheses, and all the hypotheses introduced have tobe eliminated ... typical in learn-ability theory. The negative results for Lambek- like systemsshow that this is not the case. Even placingbounds on the complexity of the types appear-ing in the grammar may not ... limit points (to be defined in Section 3) for these classes.2 The Lambek Calculus Categorial grammar originated in (Aj-dukiewicz, 1935) and was further developed in (Bar-Hillel, 1953) and (Lambek, ...

Tài liệu Báo cáo khoa học: Nuclear receptors in the mosquito Aedes aegypti Annotation, hormonal regulation and expression proﬁling ppt

... recovered,only the longest amino acid sequences that included the DNA binding, hinge and ligand-binding domainswere used for this analysis, except for the Knirps fam-ily members that lack the LBD. In D. ... libraryprepared from the fat bodies of vitellogenic femalemosquitoes. They isolated several clones that codefor a single protein. Interestingly, during the initialprocess of identifying the NR ... were incubatedfor 30 min in culture medium without hormone, followedby a 6 h incubation in the presence or absence of the hormone (10)6m 20E). To test the effect of the proteinsynthesis inhibitor...

Tài liệu Báo cáo khoa học: Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate docx

... interpretation in distinguish-ing interacting from noninteracting proteins. OneFig. 1. Schematics of library designs. The helical wheel diagram looks down the axis from the N-terminus to the C-terminus. ... focused on small molecule inhibitors, but the potential of using peptides as the starting point in the generation of therapeutics is now a growing area[18,19]. Peptides harbour the potential for chemicaland ... thisoverall value into its component kinetic steps. The ﬁndings of this study are therefore of interest to the protein design ﬁeld in general, but also inform uponhow to fast track the design of...

Tài liệu Báo cáo khoa học: Final steps in the catabolism of nicotine Deamination versus demethylation of c-N-methylaminobutyrate doc

... enzymesinvolved in nicotine catabolism will have applications not only in the bioremediation of nicotine waste, butalso in the supply of nicotine derivatives as startingmaterials for the synthesis ... lead to the complete mineraliza-tion of the pyrrolidine ring of nicotine, which afteroxidation by 6-hydroxy-l-nicotine oxidase, is cleavedoff from the pyridine ring of nicotine in the form ... from the pyrrolidine ring of nicotine.ResultsExpression of the pAO1 mao and sad-like genesrequired the presence of nicotine in the growthmedium The mao and sad genes addressed in this study are located...

Tài liệu Báo cáo khoa học: Isochore structures in the chicken genome ppt

... discussion The isochores in the chicken genomeIt should be noted that the chicken genome sequencestill contains a large number of gaps (Table 1). In the case of GGA1, there are 9847 gaps remaining. There-fore, ... denotes the first pointoccurring during the course of segmentation, and l and r denotethat the point occurs in the left and right subsequence, respect-ively. The integer denotes the times of segmentation. ... computing the G + Ccontent in sliding windows moving along the genome.Fig. 4. The negative cumulative GC profilefor GGA12 marked with the segmentationpoints obtained. The bottom five plots showthe...

Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc

... neuropathology in SE [6]. Despite numerousstudies clearly indicating the importance of enzymeactivity in the epileptic phenomenon, the mechanismsby which these enzymes in uence SE are not com-pletely ... concentrations are not raised in epileptic patients [27]. Other mechanisms maybe associated with the increase in ROS levels in the epilepsy model as well as in neurodegenerationobserved in epileptic ... ﬁndings show that pilocarpine induces SE,which can produce alterations in superoxide dismutaseand catalase activities in different areas, thereby pro-tecting the brain from neuronal damage induced...

Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf

... unusual in havingtwo histidine residues (rather than the His-Asn pairseen in OYE, MR and some of the other memberproteins; Fig. 1B) in the active site for ligand andsubstrate binding. For ... role in the binding of phenolic compounds in the active site [3,26]. Likewise, in MR the counter-part residues His186 and Asn189 form key interactionswith reducing nicotinamide coenzyme and the ... There are twomodels for productive binding of steroid substrates: in the ﬁrst, a (small) sub population of enzyme bindsdirectly the steroid in the reactive conformation, with the remainder of the...

Tài liệu Báo cáo khoa học: Proteasome involvement in the degradation of the Gq family of Ga subunits pptx

... wereremaining vs. 50–60% of the membrane fraction.These results are consistent with the idea that the Ga subunits are more stable in the membrane than in the cytoplasm. To study this further we ... RGS domain in the amino-terminus of Gprotein-coupled receptor kinase 2 inhibits Gq-mediatedsignaling. Int J Mol Med 5, 335–340.20 Chen CA & Manning DR (2001) Regulation of G pro-teins by ... degradation of the phosphoinositidaseC-linked guanine-nucleotide-binding protein Gqalpha ⁄ G11 alpha following activation of the human M1muscarinic acetylcholine receptor expressed in CHOcells....

Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc

... extracts used in the assay system.We observed that during in vitro cultivation, the L3 could not develop and molt to L4 in the presence of inhibitor, evenat the end when the culture had terminated ... determined by incubating the diluted recombin-ant proteins in the standard reaction mixture in the presenceof increasing concentrations of PPi(0.05–0.5 mM)at55°C.Data were fit to the appropriate ... rate was then calculated.Larval molting inhibition assayTo confirm whether the native PPase enzyme is involved in the molting process, we examined the effects of two PPasespecific inhibitors,...

Tài liệu Báo cáo khoa học: "Multimodal Generation in the COMIC Dialogue System" docx

... control of the underlying applica-tion. Figure 1 shows screen shots of the COMICinterface.There are four main phases in the demonstra-tor. First, the user specifies the shape of theirown bathroom, ... bound-ary tones are selected by the realiser based on the context-sensitive information-structure annotations(theme/rheme; marked/unmarked) included in the logical forms. At the moment, the other multimodalcoarticulations ... speech synthesiser to finalise the schedules for the other modalities, the synthesiserfirst prepares and stores the waveform for its inputtext; the sound is then played at a later time, when the fission...

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