... (Chry-somelidae). Their synthesis has been previously de-scribed [31-33]. For the purpose of the present study the thioglycosides used were selected and grouped based on their differences in the aglycone ... mediated by SGLT2. The clinical application of these thioglycosides, however, needs to be further analyzed. Nonetheless, our findings provide the foundation for future studies with the objective ... system, in the distal seg-ment of the tubule. Inhibition of glucose reabsorption in the kidney, mediated by the SGLT cotransport system, represents a promising therapeutic target for the control...