... family history, ethnicity, increasing age, centralobesity, physical inactivity, low HDL/high triglycerides,fasting glucose of 110 mg/dL or greater, gestational diabe-tes, hypertension, and polycystic ... [57].Recognizing early symptoms of hepatic toxicity and dis-continuing treatment are important in optimizing recov-ery. Early symptoms of hepatic toxicity include apathy,malaise, fever, diminished ... increased bioavailabil-ity of free, active highly protein-bound drugs. Accumula-tion of active hydroxylated metabolites of carbamazepinemay lead to symptoms of drug toxicity despite therapeuticdrug...