Báo cáo Y học: What does it mean to be natively unfolded? pptx
Báo cáo Y học: What does it mean to be natively unfolded? pptx
... ARTICLE What does it mean to be natively unfolded? Vladimir N. Uversky1Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow, Russia;2Department of Chemistry ... ÔboundaryÕ mean hydrophobicityvalue, <H>b, below which a polypeptide chain with a given mean net charge <R> will be most probably unfolded:hHibhRi1X1512X7851The v alidity ... atively unfo lded proteins is i ndirectly con-®rmed by their extremely h igh s ensitivity to proteasedegradation in vit ro [4,5,54±59].Table 1. Hydrodynamic characteristics of the natively unfolded...
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Báo cáo y học: "Using Medical Emergency Teams to detect preventable adverse events"
... physician (intensiv-ist during the day and a critical care resident at night), a criticalcare nurse, and a critical care-trained respiratory therapist. TheMET can be activated by any hospital ... eventdetection system at little additional cost.IntroductionMedical Emergency Teams (METs), alternatively known asRapid Response Teams, have recently been implemented inmany hospitals worldwide ... patient safetymeasure. A potential benefit of implementing an MET is thecapacity to systematically assess preventable adverse events,which are defined as poor outcomes caused by errors or systemdesign...
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Báo cáo y học: "Current Status of Methods to Assess Cancer Drug Resistance"
... mainly cytostati-cally compared with classical cytotoxic drugs require special timing of scans [68]. International guidelines for PET tests are therefore necessary to guarantee the quality and ... Chemosensitivity Vol 1, In Vitro Assays. To- towa, New Jersey: Humana Press; 2005. 31. Kern DH, Weisenthal LM: Highly specific prediction of antineoplastic drug resistance with an in vitro assay using ... are not very reliably, since many steps in the body are required to reach the target. However, their effectivity may be increased by the fact that cases of ineffective drugs can be eliminated...
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Báo cáo y học: "Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients
... Introduction Cystatin C (Cys-C) is a non-glycosylated cationic protein of 13.3 kDa, belonging to the cystatin superfamily of cysteine protease inhibitors [1, 2]. Cys-C is produced by all nucleated ... visiting Kobe University Hospital from January to July in 2002. These patients were maintained in a stable condition by the once daily oral dosing of digoxin at 0.17 ± 0.06 (0.06-0.25) mg/day, ... 0.99 (mean+ 1.96SD) mg/L in Japanese[3], with no inter-ethnic difference [4], and a higher level has been thought to be an index of renal dysfunction. The superiority of Cys-C over Cr has been...
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Tài liệu Báo cáo Y học: Studies into factors contributing to substrate specificity of membrane-bound 3-ketoacyl-CoA synthases pot
... specificitysimilar to that of A. thaliana FAE1 KCS. However, a K92Rsubstitution in thischimeric enzyme changed the specificitytothat of the B. napus enzyme without loss of catalytic activity.Thus, ... empty vector was grown under galactose inductionconditions. The VLCFA content of yeast carrying theempty vector was principally limited to 26:0 with little or noC20, C22 or C24 fatty acids ... activity andthe 22:1/20:1 product ratio. Our goal was to identify thesmallest domain required to retain a particular substratespecificity and to engineer an enzyme with novel activity.Twenty-nine...
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Báo cáo Y học: Solution structure of the HIV gp120 C5 Domain pptx
... Recently,the structure of HIV gp120 in complex with regions of theCD4 receptor and a monoclonal antibody that blocks gp120binding to the chemokine receptor has been determined byX-ray crystallography ... which are largely missing in the crystal structurebut would be expected to be proximal to one another, areinvolved in the interaction with gp41 [8,9]. Furthermore, it has recently been shown that ... groups to the amino andcarboxy termini, respectively. The identity of the peptidewas verified by mass spectrometry (mass ¼ 2700.9). Thewild-type HIV gp41 ectodomain was prepared as previouslydescribed...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... factor in theregulation of WD promoter activity.Comparison of WD promoter activity in Ku-deficientXrs-5 cells to the activity in CHO cells To verify that Ku-80 is an essential regulatory factor ... intensity of WD cDNA/intensity of competitor and then divided by intensityof amplified actin cDNA. PC, the result of competitive RT-PCR using mRNA isolated from nontransfected HepG2 cells as a positive ... incubated with a32P end-labelled MREa probe as described in Materials and methods and subjected to autoradiography. A 70-kDa polypeptide is indicated by solid arrowhead. (B) SDS/PAGE analysis of...
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Báo cáo Y học: Regulation of peptide-chain elongation in mammalian cells pptx
... ADP-ribosylated by diphtheria toxin[25]. ADP-ribosylation inhibits the activity of eEF2.Phosphorylation of eEF2 inhibits its activity, in translo-cation and in poly(U)-directed polyphenylalanine synthesis[26,27], ... way to enhance its intracellular activity than rendering it independ-entofCa2+ions. This is because intracellular Ca2+ionconcentrations fluctuate on a beat -to- beat basis in cardio-myocytes, ... blocked byrapamycin, again revealing a link to mTOR. Given thatSAPK4 is not activated by IGF1, and that it is not known to be regulated by mTOR, it seems likely that there is anadditional,...
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Báo cáo Y học: Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the a or b catalytic subunit potx
... differen-tially dephosphorylated by CaNa and CaNb in vivo.The differences in phosphatase activity and sensitivity to FKBP12/FK506 or CyPA/CsA inhibition between CaNaand CaNb that we observed may be due to ... andsubstrate may influence the degree of inhibition of CaNphosphatase activity by FKBP12/FK506 and CyPA/CsA.The differences in phosphatase activity and sensitivity to FKBP12/FK506 inhibition between ... CnAactivates the enzyme by relieving inhibition due to anautoinhibitory domain, which is evidenced by an increase inVmax[11,31]. Conversely, Ca2+-binding to CnB activatesCaN primarily by affecting...
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Báo cáo Y học: Mistletoe viscotoxins increase natural killer cell-mediated cytotoxicity pptx
... of bystander cells. (A)Enhancement of NK cytotoxicity cannot be reproduced by a VTA2 pulse of effector or target cells before the lysis assay. The effector cells or targetcells were separately ... highly purifiedviscotoxins alone enhance the efficiency of tumor celllysis by NK cells in the absence of any direct cytotoxicity to the target. Although the mode of viscotoxin actionhas not been ... activity was assessed in a 4-h51Cr-release assayin which effector cells (NKL, NK-92, freshly isolated NK orcd cytotoxic T lymphocytes) were mixed with differenttarget cells. Lysis assays were...
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Từ khóa: 3 what does it mean to speak of a cancer s originwhat does it mean to use a personwhat does it take to be a successful authorwhat does it take to be c4báo cáo y họcbáo cáo y họcbáo cáo y học cổ truyềnarticle in press what does it meanmẫu báo cáo y học cổ truyềnbao cao y hoc colchicinphan ban luan trong bao cao y hoc co truyenwhat does it mean if a journal article is in presswhat does it meanwhat does it mean that israel did not quot attain the law quot because she pursued it quot not by faith but as though it were by works quotborn but what does it meanchuyên đề điện xoay chiều theo dạngNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM