... application of laser energy. Sometimes, the extent of disease or the location of the lesions may preclude completeeradication. Also, co-morbid conditions must beconsidered and may occasionally ... on the nature and quality of the evidence.For example, if there is only one good randomizedcontrolled trial (RCT), the results of that one trialalone may be used in the outcomes tables. Otherstudies ... addition, there is little information defining the optimal dose, number and timing of instilla-tions or the influence of long-term maintenancetherapy. Randomized studies supporting the use of maintenance...