Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide ppt

... The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth ... presence of EDTA. The rough S. minnesota LPS increased the initial fast phase of the reaction, but decreased the rate of the slow phase of oxidation in the presence of EDTA. A comparison of rough and ... Tsuruga and Shikama [21] conﬁrmedthat the fast phase of oxidation was due to the a chains and the slow phase was due to the bchains. Tsuruga et al. foundthat the beta chain of the tetramer does...

Tài liệu Báo cáo khoa học: An autoinhibitory effect of the homothorax domain of Meis2 ppt

... possibly of other Meis paralogs, may play a role in regulating transcriptional activity, but itappears that the Hth domain does not maintain the cytoplasmic localization of Prep1. Additionally, the greatest ... ifinteraction of Pbx1 with the Hth domain altered the conformation or intramolecular interactions, allowingaccess to the AD. As the autoinhibition affected anunrelated AD when this was put in place ... presented as the mean + standard devia-tion of duplicate transfections (arbitrary units). (C) A series of Meis2 and Prep1 deletion constructs fused to the GBD were assayed as in (A) . (D) The relative...

Tài liệu Báo cáo khoa học: Co-operative effect of the isoforms of type III antifreeze protein expressed in Notched-ﬁn eelpout, Zoarces elongatus Kner ppt

... isoforms of nfeAFP and ana-lyzed the thermal hysteresis (TH) activity of each as a function of pro-tein concentration. We also examined the change in activity on mixing the isoforms. TH was ... Nishimiya1, Ryoko Sato1, Manabu Takamichi2, Ai Miura1 and Sakae Tsuda1,21 Functional Protein Research Group, Research Institute of Genome-based Biofactory (RIGB), National Institute of Advanced ... smallamount of a QAE1 isoform, nfeAFP8 (Fig. 7). This issimilar to the case of the QAE2 isoform, nfeAFP13; the activity of its monomer was enhanced by the pres-ence of a small amount of the...

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

... indicated that the RasGEF activity of v-KIND induces the phosphoryla-tion of MAP2 by JNK1 and ⁄ or ERK via the activation of the Ras–Raf–MAP kinase pathway [12]. These resultsappear to be in agreement ... exchangefactor and microtubule-associated protein 2, and its rolein dendrite growth – structure and function of the secondkinase noncatalytic C-lobe domainJinhong Huang1,*, Asako Furuya1, ... signal transduction path-ways [1,2]. The kinase noncatalytic C-lobe domain(KIND) was determined to be a putative signalingdomain based on bioinformatic analysis of the N-ter-minal sequence of...

Báo cáo khoa học: Retrocyclin RC-101 overcomes cationic mutations on the heptad repeat 2 region of HIV-1 gp41 ppt

... one was found in gp120 and oneeach in the HR1 and HR2 regions of gp41, and allthree mutations converted a polar or anionic residue to a cationic residue [14]. In addition, the cationic muta-tion ... residues of HR2 that interacted with RC-101, and then analyzed the HIV-1 sequence database at Los Alamos National Laboratory (NewMexico, USA) for residue variations in the heptad repeat 1 (HR1) and HR2 ... including bacteria, fungi and viruses [1]. There are three major defensinfamilies (a, b and h). They are classiﬁed based on their b-sheet conformation, cationic charge and unique disulﬁde bond pattern...

Báo cáo khoa học: Gene expression silencing with ‘speciﬁc’ small interfering RNA goes beyond speciﬁcity – a study of key parameters to take into account in the onset of small interfering RNA off-target effects potx

... [25–28]. The method is based on a system with two arrays on a glass slide and three identical subarrays (triplicate spots)per array. The reliability of hybridizations and experimentaldata was evaluated ... ⁄siRNA2, LAMP2 ⁄ siRNA1 and LAMP2 ⁄ siRNA2 are 5¢-UGACUUCCCUGGCCUAUUUUU-3¢,5¢-ACAUUGAGCUCCUCUCUUGUU-3¢,5¢-GAUAAGGUUGCUUCAGUUAUU-3¢ and 5¢-ACAGUACGCUAUGAAACUAUU-3¢,respectively. As a negative ... (forward, 5¢-GGCCCAGGTGACTCAGCTATT-3¢; reverse, 5¢-AGGGCATCCGAGAATTCCTT-3¢), LAMP2 (forward, 5¢-TCAGCATTGCAAATAACAATCTCA-3¢; reverse, 5¢-CAGTCTGCTCTTTGTTGCACATATAA-3¢), CTGF (forward, 5¢-CAAGCTGCCCGGGAAAT-3¢;...

Tài liệu Báo cáo khoa học: Hsp105b upregulates hsp70 gene expression through signal transducer and activator of transcription-3 pdf

... 5¢-TCT ATC TCT CGA TGGATA CAG A- 3¢; reverse, 5¢-AGG ACA GTA GAA TTAGGT CAC T-3¢).Knockdown of Hsp10 5a and Hsp105b The double-stranded RNA targeting Hsp105 (Dharmacon;5¢-GCA AAU CAC UCA UGC AAA ... Stephanou A, Isenberg DA, Nakajima K & LatchmanDS (1999) Signal transducer and activator of transcrip-tion-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and ... Yasuda K, Nakai A, Hatayama T & Nagata K (1995)Cloning and expression of murine high molecular massheat shock proteins, HSP105. J Biol Chem 270, 29718–29723.9 Ishihara K, Yasuda K &...

Tài liệu Báo cáo khoa học: "Parsing, Projecting & Prototypes: Repurposing Linguistic Data on the Web" doc

... Because the ﬁeld of linguisticshas as its mandate the study of human language—infact, the study of all human languages and has whole-heartedly embraced the Web as a means for dissemi-nating ... limited annotated data. The resource, the Online Database of INterlinear text (ODIN), makesthis data available and provides additional annotation and structure, making the resource useful to the ... knowledge, the consequence is that a large quantity of analyzed language data can be found on the Web. In many cases, the data is richly annotated and exists for many languages for which there wouldotherwise...

Tài liệu Báo cáo khoa học: RMI1 deﬁciency in mice protects from diet and genetic-induced obesity pptx

... strain as described below). Body and organ weights as well as plasma parameters(Tables S2 and S3) were measured, and learning, mem-ory and behavioral tests (Table S4) as well as histo-pathological ... Matsumoto2, Takeshi Kurama1, Teruhiko Shimokawa1 and Ichiro Aramori21 Pharmacology Research Labs, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan2 Molecular Medicine Labs, Astellas Pharma ... T, Sakaue H, Nakamura T, Okada M, MatsukiY, Watanabe E, Hiramatsu R, Nakayama K, Nakay-ama KI & Kasuga M (2007) Skp2 controls adipocyteproliferation during the development of obesity. J...

Tài liệu Báo cáo khoa học: Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast doc

... capacity of the enzyme, i.e. when the capacity was high, the capacity of the less-diluted samples was not proportional to that of the other samples. In a few cases, the capacity of the enzymewas so ... regulationanalysis has been developed [10].Regulation analysis has the rate through an enzyme(v) vary proportionally to a function f that depends on enzyme concentration (e), and to a function ... the capacities of hexokinase (HXK), aldolase(ALD), PGK, GPM, PYK and pyruvate decarboxylase(PDC) were upregulated. The capacity of alcohol dehy-drogenase (ADH) was downregulated and the capaci-ties...

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