Báo cáo Y học: Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions pot
Báo cáo Y học: Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions pot
... 2002 Binding of apolipoprotein E3 and E4 to emulsions (Eur. J. Biochem. 269) 5949 Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions Matthew ... that apoE3 and apoE4bind preferentially to small and large lipid particles,respectively.Direct binding analysis of ApoE3 and ApoE4 to largeemulsion particles To verify and quantify the size-dependent ... interaction of apoE3 and apoE4 to fractionated lipid emulsions, we alsoemployed a direct binding using Myr2Gro-PCho /TO fraction 6 and physiological concentrations of apoE. The binding isotherms...
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Tài liệu Báo cáo Y học: Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D -erythritol 2,4-cyclodiphosphate in plants docx
... 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, 4-diphosphocytidyl-2C-methyl-D-erythritolkinase and 2C-methyl-D-erythritol 2,4-cyclodiphosphatesynthase [24–26] (Fig. 1). In the meantime, some of ... analyzed by HPLC in order to monitor the conversion of [1-3H]2C-methyl-D-erythritol 4-phosphateinto the corresponding 2,4-cyclodiphosphate. The organicphase was analyzed for3H and 14C in ... effici-ently to the 2C-methyl-D-erythritol 2,4-cyclodiphosphateFig. 3.13C NMR signals of 2C-methyl-D-erythritol 2,4-cyclodiphosphate obtained by incubation of [U-13C5]2C-methyl-D-erythritol4-phosphate...
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Tài liệu Báo cáo Y học: Mutations in the docking site for cytochrome c on the Paracoccus heme aa3 oxidase Electron entry and kinetic phases of the reaction pptx
... complex of the respiratory chains of mitochondria and many bacteria[1–4]. It catalyzes the reduction of oxygen to water, coupling the free energy of this reaction to the generation of a protongradient ... set of mutants in surface-exposed residues to further identifyamino acid side chains involved in the docking of cytochrome c, or in the presumed electron entry fromcytochrome c to the CuAcenter. ... not maintained by the neighbouring tyrosine,while the W121F /Y1 22F mutant activity may be viewed asa commitment of the tyrosine residue to support the (somewhat higher) residual activity of the...
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Báo cáo y học: "Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary"
... 66.83 per 1000 informative offspring in the 1980s and within this, the total rate of major congenital abnormalities was 27.01 per 1000 informative offspring [1,2]. The causes of congenital ... the spectrum of congenital abnormalities evaluated, the period of study (only at birth or in early neonatal period or prenatal or the whole infant period are included), the completeness of ... frequently terminated if the fetus is severely affected. Thus, the rate of defects is calculated for informative offspring including (i) live born infants, (ii) stillborn fetuses, and (iii)...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... environ-ment of tryptophan residues is essentially conserved in the mutant enzyme. On the other hand, the absence of major differences in the CD spectra of the wild-type and D153Nagmatinases indicates ... connecting aminoacids at the beginning and the end, were mutated to glycines and, after remodelling back to their side chains in agma-tinase, the whole hydrogen bond network was optimized. The ... investigation in our laboratory. In any case,despite the structural differences between agmatinase and arginase, agmatine and arginine were fixed in essentially the same position in the corresponding active...
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Báo cáo khoa học: "Search in the Lost Sense of “Query”: Question Formulation in Web Search Queries and its Temporal Change" pptx
... questions to ex-press their search intent.1 IntroductionA web search query is the text users enter into the search box of a search engine to describe their infor-mation need. By dictionary definition, ... largely lost the orig-inal semantics of the word query: they tend to befragmented phrases (“banana calories”) instead of questions. This could be a result of users learning to express their information ... observe how the fraction of query traffic con-taining the phrase1changes over time. For instance,as shown next, the fraction of query traffic contain-ing “how to has in fact been going up since...
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Báo cáo khoa học: Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa potx
... photoactivation. Both the stability of the mutants and their ability to activateGt could be correlated with the increase in size of the side-chain at position 51, pointing to a disruption of the interhelical ... (1996) Structure and function in rhodopsin: correct folding and misfolding in point mutants at and in proximity to the site of the retinitis pigmentosa mutation Leu-125–>Arg in the transmembrane ... and of the opsin bound to a peptide derivedfrom the C-terminus of transducin (Gt) unravelled keyfeatures regarding the interaction between the receptor and the G-protein, as well as the main...
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Báo cáo khoa học: A hydrophilic cation-binding protein of Arabidopsis thaliana, AtPCaP1, is localized to plasma membrane via N-myristoylation and interacts with calmodulin and the phosphatidylinositol phosphates PtdIns(3,4,5)P3 and PtdIns(3,5)P2 pptx
... 7. An amino-terminal polybasic region is necessary for specific binding of PCaP1 to the phosphatidylinositol moiety. (A) The capacity of binding of PCaP1 to PtdInsP s (abbreviations as in Fig. ... PCaP1tightly binds to the plasma membrane via N-myristoy-lation at Gly2 and specifically interacts withPtdIns(3,5)P2 and PtdIns(3,4,5)P3 in the membrane.N-myristoylation anchors PCaP1, and the interactionwith ... membrane via N-myristoylation at Gly2. We examined the binding capacity with phosphatidylinositol phosphates (PtdInsPs), and found thatPCaP1 selectively interacts with phosphatidylinositol 3,5-bisphosphate...
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Báo cáo Y học: Concentration-dependent reversible activation-inhibition of human butyrylcholinesterase by tetraethylammonium ion pptx
... protein modelingFig. 1. pS c urves for the hydrolysis of butyryl-thiocholine c atalyzed by the w ild-type, by v ar-ious human butyrylcholinesterase mutants and by horse butyrylcholinesterase in ... BuChEs. Twoamino-acid residues (D70 and Y3 32) in the PAS and two(W82 and A328) in the CS, known to play a role in the binding of positively charged ligands and in inhibitioncontrol of BuChE, were ... visible in the wild-type enzyme, in the A32 8Y mutant and in the ÔcompensatoryÕ mutant (Y3 32D/D7 0Y) . It can only be perceived in Y3 32A/D70Gmutant but is absent in the W82A and in horse enzyme. (b)In...
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Báo cáo Y học: Substrates modulate the rate-determining step for CO binding in cytochrome P450cam (CYP101) A high-pressure stopped-flow study pdf
... its keto group and the hydroxyl group of the amino-acid residue Tyr-96, and (b) by hydrophobic contacts of its methyl groups C-8, C-9 to Val295 and Asp297 in the b3sheet, and of the methyl group ... iron ligand is a good probe for the polarity and therefore for the presence of water molecules in the heme environment of cytochrome P450cam. To get a further insight into the dynamics of the waterexchange ... substrate binding. The positive sign of the activation volume for CO binding is rather indicative forsolvent accessibility and flexibility of the protein than fordiffusion-controlled CO binding or...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018chuyên đề điện xoay chiều theo dạngNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ