... fatty acids or their metabolites are agonists for PPAR-d or antagonists for PPAR-c, and this is themolecular basis for cancer formation, at least in some model systems. These theories merit further ... acids, KASL [49]. These studies wereperformed before the existence of the minor splice vari-ants [81–83] was known, and therefore refer to AMA-CR 1A, the major form of the enzyme in ‘normal’ cells.Examination ... anddisease, with a particularly strong correlation with prostate cancer [11,12]. This review will look at recentprogress in understanding branched-chain fatty acidmetabolism and its link with cancer....