Báo cáo khoa học: "Analysis and Synthesis of the Distribution of Consonants over Languages: A Complex Network Approach" pptx
Báo cáo khoa học: "Analysis and Synthesis of the Distribution of Consonants over Languages: A Complex Network Approach" pptx
... 21 consonants. We further as-sume that the consonants are arranged in their hier-archy of preference. A language traverses the hier-archy of consonants and at every step decides with a probability ... Consonants over Languages: A Complex Network ApproachMonojit Choudhury and Animesh Mukherjee and Anupam Basu and Niloy GangulyDepartment of Computer Science and Engineering,Indian Institute of ... defined as the average difference between the ordinate pairs where the abscissas are equal.• Provide a simplified mathematical model tosupport our analytical explanations, and • Develop a synthesis...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... autoamplificatory signaling loop. Mutualamplification of shrinkage and ROS triggers apoptosis,which could be prevented by NAPDH oxidase inhibi-tors and the availability of antioxidants and osmolytes.In ... howosmosensing and osmosignaling integrate into the overall context of growthfactor signaling and the execution of apoptotic programs.AbbreviationsEGF, epidermal growth factor; MAPK, mitogen-activated ... factor(EGF)-receptor, the association of CD95 with the EGF-receptor, and phosphorylation of CD95 onTyr232 and Tyr291 by the EGF-receptor tyrosinekinase activity [15]. Although the appearance of CD95at the plasma...
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Tài liệu Báo cáo khoa học: Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc docx
... University of Western Australia, Crawley, Australia2 Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA3 Department of Pharmacognosy ... tissues such as the adre-nal gland may receive vitamin D from the bloodstreamfor further metabolism [4].In conclusion, the identification of new metabolites of vitamin D3 made by the action of P450scc ... metabolism, the hormonally active form of vitamin D3, 1a, 25-dihydroxyvitamin D3, displays anti-cancer, immunoregulatory and endocrine effects, and is also a potent antiproliferative and differentiation-inducing...
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Báo cáo khoa học: Flexibility and communication within the structure of the Mycobacterium smegmatis methionyl-tRNA synthetase Henrik Ingvarsson and Torsten Unge potx
... between the prokaryotic and eukaryotic enzymes, the availability of enzymematerial and access to structural information [1–3].Furthermore, the potential of aaRSs as drug targetshas been illustrated ... Class 1 aaRSs are characterized by the aminoacid sequence motifs HIGH and KMSKS, and byhaving a catalytic domain with a classical Rossmann-fold topology [13–16]. Class 2 aaRSs have their active-site ... helix a4 of the catalytic domain, the N-terminal end of strand b4 and helix a5 , and the C-terminal end of strand b8 belonging to the CPdomain (Figs 1 and 2). Each MetRS binds one phos-phate molecule...
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Tài liệu Báo cáo khoa học: Enzymatic and electron paramagnetic resonance studies of anabolic pyruvate synthesis by pyruvate: ferredoxin oxidoreductase from Hydrogenobacter thermophilus doc
... Ozawa Y, Nakamura T, Kamata N, Yasujima D,Urushiyama A, Yamakura F, Ohmori D & Imai T(2005) Thermococcus profundus 2-ketoisovalerateferredoxin oxidoreductase, a key enzyme in the archaealenergy-producing ... 8.0). The assaymixture without NADH and acetyl-CoA was incubated at70 °C under an argon atmosphere. The reaction was startedby adding the NADH, acetyl-CoA and enzyme solutions to the mixture, and ... results). The enzyme activity of the recombinant LDH was assayed at 70 ° C by monitoring the lactate-dependent NADH oxidation as the decrease in A 340. The standard assay mixture contained 1 mm lactate,0.2...
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Tài liệu Báo cáo khoa học: "Analysis and Repair of Name Tagger Errors" pptx
... describing them in further detail. 6 Experimental Results and Analysis Table 4 shows the data used to train each stage, drawn from the ACE training data and other sources. The training samples of the ... structure parsing results too, such as the family name and given name of person, the prefixes of the abbreviation names, the modifiers and suffixes of organization names. Then the results ... include the best hypothesis, as a function of the margin. We then divide the margin into ranges of values, and set a value of N for each range, with a maximum of 30. High-Confidence Ranking...
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Báo cáo khoa học: An intermediate step in the evolution of ATPases ) the F1F0-ATPase from Acetobacterium woodii contains F-type and V-type rotor subunits and is capable of ATP synthesis Michael Fritz and Volker Muller ¨ docx
... in bacteria, mitochondria and chloroplasts, the A 1 A 0-ATP synthase present inarchaea, and the V1V0-ATPase present in eukarya[1,2]. A common feature of ATP synthases ⁄ ATPasesis their ... An intermediate step in the evolution of ATPases ) the F1F0-ATPase from Acetobacterium woodii contains F-type and V-type rotor subunits and is capable of ATP synthesis Michael Fritz and ... domaincatalyzes ATP hydrolysis [6,7], whereas the membranedomain translocates ions from one side of the membrane to the other against their electrochemicalgradient [8,9].ATP synthases⁄ ATPases are...
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Báo cáo khoa học: Analysis and biological relevance of advanced glycation end-products of DNA in eukaryotic cells ppt
... were asfollows: b-actin – hsbact-S3-391 (5¢-TGA GAC CTT CAACAC CCC AG-3¢) and hsbact -A5 -1046 (5¢-CAT CTG CTGGAA GGT GGA CA-3¢); b-galactosidase – b_Gal_F (5¢-AAT CGT CTG ACC GAT GAT CC-3¢) and ... separated on agarosegels, and the amount was determined semiquantitatively. Relativeluciferase activity was defined as the ratio of luciferase to a co-transfected b-galactosidase mean value relative ... byDNA-advanced glycosylation endproducts. Proc NatlAcad Sci USA 90, 2666–2670.28 Murata-Kamiya N, Kamiya H, Kaji H & Kasai H(1997) Glyoxal, a major product of DNA oxidation,induces mutations...
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Tài liệu Báo cáo khoa học: Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus doc
... measured at the interface between a solid and a liquid phase, and cal-culated as the ratio of two rate constants. However,values of DDG and DDG¢ for mutant Fab fragments,calculated from values ... wells of a microtiter plate and the boundFab4E11-H6 was revealed with a goat antibody, directed againstmouse Fab and conjugated with alkaline phosphatase. The totalconcentration of MalE-E3-H6 ... anti-bodies and their genes, and performed a systematicscanning of the CDR3 loops of mAb4E11 by mutagen-esis of their residues into alanine (Ala scanning). The affinities of the purified mutant Fab fragments...
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Tài liệu Báo cáo khoa học: Unfolding and aggregation during the thermal denaturation of streptokinase pptx
... temperature provides the heat capacity relative to N, also known as the excessheat capacity. The addition of the heat capacity of the native state, Cp(N), gives the total heat capacity of the protein:Cp¼ ... protein aggregation occursduring the thermal denaturation of intact SK and of the isolated A domain. The presence of these aggregationprocesses has a profound effect on the DSC curves and precludes ... from these equations using the following set of parameters: a linear heat capacity function for the nativestate, Cp(N); the enthalpies and the heat capacities of the unfolded state, DHUand...
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