... 2004
MINIREVIEW
Genetic defects in fatty acid b-oxidation and acyl-CoA dehydrogenases
Molecular pathogenesis and genotype–phenotype relationships
Niels Gregersen
1
, Peter Bross
1
and Brage S. Andresen
1,2
1
Research ... heart, liver and/ or the
neuromuscular systems.
Deficiencies in the transporters and enzymes involved in
the oxidation of long-chain fatty acids are generally s...
... ubiquitously in a
broad range of organisms from Escherichia coli to humans
[1–3]. Two cyclophilins, E. coli CyPA and E. coli CyPB,
have been identified [4,5], and at least five cyclophilins in
mammals ... (mutant residue) and Leu165 on the
b8 strand, and through Leu8 and Thr10 side chains on the
b1 strand. In the crystal of free CyPB, a crystallographic
twofold rotation axis i...
... are
immiscible with water and that have low polar characteris-
tics (hexane, diisopropyl ether, and 3-pentanone), and those
that have polar properties and are water miscible (ethanol
and acetonitrile).
System ... hydration studies on
dry proteins. There is a striking similarity between
the water-adsorption properties of proteins in air and
in organic solvents [13]. Early studie...
... Igor Twoodore, and Igore Twoodore.
We estimate phonetic similarity between a source
and target entity by computing Levenshtein and
other distance metrics between the source entity
and the closest ... of the English sentence. Different and
possibly conflicting NE tags for candidate English
and foreign sentence substrings according to the
Wiki-based taggers and the Stanford tagger...
... of
Escherichia coli PFK (PDB code 4pfk [12]). This was
the most suitable template, given our interest in both
catalytic and regulatory sites, among the various available
structures of E. coli and ... muscle
enzyme and the catalytic subunit of S. cerevisiae,andthePP
i
-depen-
dent enzymes of E. histolytica, A. methanolica and P. freundenreichii.
Sequences of yeast and human exp...
... MESR
fellowship.
References
1 Magalon A & Mendel RR (2008) Biosynthesis and
insertion of the molybdenum cofactor. In
EcoSal Escherichia coli and Salmonella: cellular and
molecular biology (Bo
¨
ck A, Curtiss R III, ... NarG(1–15) and (B)
NarG(1–28).
A
B
Fig. 2. (A) Sequences of NarG(1–15) (left) and NarG(1–28) (right) and sequential assignments. Collected sequential NOEs ar...
... imper-
meable to the Coenzyme A thioesters of long-chain fatty
acids, these activated derivatives, which are synthesized
from nonesterified fatty acids by fatty acyl-CoA synthetase
on the cytosolic aspect ... Membrane transport of fatty acylcarnitine and free
L
-carnitine
by rat liver microsomes
Jason M. Gooding, Majid Shayeghi and E. David Saggerson
Department of Biochemistry and...
... in the context of cutin and
suberin studies [1,2]. These protective biopolymers are
made mostly of hydroxyfatty acids and a,x-dicarbox-
ylic acids esterified to each other and to glycerol. The
hydroxyl ... Gerhardt B (1992) Fatty acid degradation in plants.
Prog Lipid Res 31, 417–446.
53 Koiwai A & Matsuzaki T (1988) Hydroxy and normal
fatty acid distribution in stigmas o...