Báo cáo khoa học: Pleiotropy of leptin receptor signalling is deﬁned by distinct roles of the intracellular tyrosines docx

... al. Pleiotropic leptin receptor signalling FEBS Journal 272 (2005) 109–119 ª 2004 FEBS 119 Pleiotropy of leptin receptor signalling is deﬁned by distinct roles of the intracellular tyrosines Paul ... suppressor of cyto-kine signalling 3 (SOCS3) [15,23–26]. Binding of SOCS3 to Tyr-985 attenuates leptin signalling by inhi-bition of the receptor- associated JAK kinase [25]. Incontrast, recruitment of ... indicatingthat essential components of the AMPK pathway werepresent in these cell lines.Role of the intracellular tyrosine residuesin LEPRbTo determine the role of the three intracellular tyrosineresidues...

Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx

... relapseand ⁄ or metastasis after complete excision of the cancer, even if they were at stage IA [3]. Despite the progress that has been made in recent decades, the mechanism of lung cancer development, ... subset of human lung cancersTo gain further insights into the role of miR-125a-5pin lung carcinogenesis and to examine the clinical rele-vance of our ﬁndings, we investigated the expression of ... three cell lines, and that thiseffect was reversed by geﬁtinib. The value for miR-125a-5p in the EGF group was set at 1, and the relative amounts of miR-125a-5pin the other groups were plotted...

Báo cáo khoa học: 15-Deoxy D12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor c in human erythroleukemia cells ppt

... cells and thisbinding was shown to be independent of 15d-PGJ2stimulation.Thereafter, the precise site of action of 15d-PGJ2was identiﬁed by further 5¢ deletion analysis dissecting the )192 ... (2002) Characteri-zation of the 5¢ untranslated region of alpha and betaisoforms of the human thromboxane A2 receptor (TP).Differential promoter utilization by the TP isoforms.Eur J Biochem 269, ... activation on the expression of a number of pro-atherosclerotic, pro-thrombotic and a range of other critical vascular-related genes [16,17]. This is sup-ported by clinical data whereby PPARc agonists...

Báo cáo khoa học: G protein-coupled receptor 30 down-regulates cofactor expression and interferes with the transcriptional activity of glucocorticoid pdf

... down-regulated cofactor expressionin hTERT-HME cellsGR affects gene transcription by a mechanism which is enhanced by cofactors. We therefore characterized the effect of GPR30 on the expression of receptors ... hormone resistance by GPR30.GPR30 most probably a lso induces glucocorticoidresistance by mechanisms other than down-regulation of TIF2 expression. Ligand binding is the main inducer of the transcriptional ... further sought to identify the mechanism by whichGPR30 would interfere with GR mediated activation of transcription. We established that GPR30 down-regulated the expression of cofactor TIF2. The...

Tài liệu Báo cáo khoa học: 1,5-Diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases ppt

... higherthan that for DABY and PSAO (r ¼ 17) [7]. From thispoint of view, plant CAOs are more resistant to the inactivation by DAPY than by DABY. Binding of DAPYat the active site of GPAO is dependent ... general base at the active site [3]. This step is followed by hydrolytic release of the aldehyde product and the reduced cofactor is ﬁnallyreoxidized by molecular oxygen with the release of H2O2and ... 4-amino-2-butynalproduct from DABY, so that there is greater turnoverprior to inactivation.To obtain clues as to the mechanism of inactivation of GPAO by DAPY, we investigated the inhibitory potency of the two possible...

Báo cáo khoa học: " New Ranking Algorithms for Parsing and Tagging: Kernels over Discrete Structures, and the Voted Perceptron" docx

... entities on the test set, and of these are correct then the precision of a method is .Similarly, if is the number of entities in the human annotatedversion of the test set, then the recall is .P ... examples is . The run-ning time of the algorithm in ﬁgure 1(b) is .This follows because throughout the algorithm the number of non-zero dual parameters is bounded by , and hence the calculation of ... per-ceptron is preferable in cases of noisy or unsepara-ble data. The training phase of the algorithm is un-changed – the change isin how the method is appliedto test examples. The algorithm...

Báo cáo khoa học: Complement factor 5a receptor chimeras reveal the importance of lipid-facing residues in transport competence doc

... or the inter-action of the calcitonin -receptor- like receptor and the receptor- activity modifying proteins to dictate the ligand specificity of the receptor [14].Another possibility is that the ... affinity of the receptors in the ER may be the result of severalmechanisms: (a) the cholesterol content of the ERmembrane is different from that of the plasma mem-brane and the high-affinity ... determine whether the decrease in binding affinity in the other chimeraswas the result of protein instability and misfolding orwas merely a byproduct of the localization of chimerasin the ER, cells...

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

... Cohen’sdiscovery of the ‘tooth-lid factor’ led to the identiﬁca-tion of the genetic causes of certain types of humancancers, and to the genetic classiﬁcation of a variety of tumors of apparently the ... ledto the discovery that EGFR is a tyrosine kinase acti-vated by binding EGF [1]. In 1984, the cDNA of human EGFR was isolated and characterized. A highdegree of similarity was found between the ... (TRU)-type of adenocarcinoma [16]. This type of cancer is charac-terized by distinct cellular features (expression of thyroid transcription factor 1 and surfactant proteins,and lepidic growth in the...

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

... opening a new vista for genotype-directedtherapy in this disease.KRAS mutation as a mechanism of resistance to EGFR-targeted therapy The KRAS protein is localized to the inner surface of the cell ... reposition-ing of critical residues surrounding the ATP-binding cleft of the tyrosine kinasedomain of the receptor and thereby stabilize the interaction with EGF-TKIs.Table 2. Prospective study of EGFR-TKI ... repositioning of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and therebystabilize the interaction with EGF-TKIs, leading to anincrease of  100-fold...

Tài liệu Báo cáo khoa học: Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 pdf

... surface of the cell that pro-duced them. The ECM can be found in differentforms, from the hard compositions of bone to the softstructures of connective tissue. Collagens are the maincomponents of ... level of S100A4 showed a greater reduction in the synthesis of TIMP-1 than did those with a low level of S100A4. Taken together, this studyshows that synthesis and activation of MMP-2 is affected ... proliferation and apoptosis [11]. AlthoughS100A4 is strongly associated with the stimulation of invasion and metastasis, the actual mechanism for the metastasis-promoting function of S100A4 is not com-pletely...

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