Báo cáo khoa học: Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives pdf
Báo cáo khoa học: Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives pdf
... 2673–2683 ª 2006 The Authors Journal compilation ª 2006 FEBS 2683 Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives Elena J. Rossi1,2,*, Lyann Sim1,2,*, Douglas ... miglitol (2), salacinol (3) and kotalanol (4); (5–7) are derivatives of salacinol with substi-tutions in the ring. (8–9) are ring expanded salacinol derivatives. (10 )and( 11) are miglitol derivatives. ... deriv-atives, against active human recombinant MGAnt. By confirming the higher potency of salacinol and its derivatives against human MGAnt as compared witha-amylase and fungal glucoamylase, our results...
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Tài liệu Báo cáo khoa học: Inhibition of glyceraldehyde-3-phosphate dehydrogenase by peptide and protein peroxides generated by singlet oxygen attack docx
... inactivation of G APDH being metal-ion independent, whereas inhibition of GR and LDH by H2O2occurs most rapidly in the presence of metal ions.It is proposed that the inhibition of GAPDH and GR by these1O2-generated ... in its1Dgstate;1O2)isgenerated by a number of enzymatic and chemical reactions, by UV exposure, and by visible light in the presence of anumber of exogenous or endogenous cellular sensitisers.1O2generation ... exposure of humans to UV and visible light,1O2hasbeen sugge sted t o p lay a key role in the development of anumber of human pathologies including cataract, sunburn,some skin cancers and aging...
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Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx
... reactions of trans-sulfura-tion through the production of homocysteine, biologi-cal methylations of DNA, lipids and proteins, and polyamine biosynthesis through the production of methionine and S-AdoMet ... result of this approach indicated the orienta-tion of 5-methyltetrahydrofolate in the MetS activesite. Figure 5 shows the superimposed structures of DHPS and 5-methyltetrahydrofolate. The model of ... TA (1991) Inhibition of vitamin B12-dependentmethionine biosynthesis by chloroform and carbontetrachloride. Biochem Pharmacol 42, R25–R28.16 Smith JR & Smith JG (1990) Effects of methylmercuryin...
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Báo cáo khoa học: Inhibition of the mitochondrial calcium uniporter by the oxo-bridged dinuclear ruthenium amine complex (Ru360) prevents from irreversible injury in postischemic rat heart docx
... The purity of these fractions was determined by measuring theactivities of d-glucose phosphate phosphohydrolase and 5¢-ribonucleotide phosphohydrolase for the microsomalfraction and of cytochrome ... modulation by endogenous effectors, drugs and diesterasases. Phar-macol Rev 49, 1–51.14 Ying WL, Emerson J, Clarke MJ & Sanadi DR (1991) Inhibition of mitochondrial calcium ion transport by an ... mitochondrialmembrane lipid composition and Ca2+activation of PDH. Am J Physiol 276, H149–H158.24 Di Lisa F, Menabo R, Barbato R & Siliprandi N (1994)Contrasting effects of propionate and propionyl-l-carni-tine...
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Tài liệu Báo cáo khoa học: "Part-of-Speech Tagging for Twitter: Annotation, Features, and Experiments" pdf
... source of user-created content, and a flurry of recent research has aimed to under-stand and exploit these data (Ritter et al., 2010; Shar-ifi et al., 2010; Barbosa and Feng, 2010; Asur and Huberman, ... of our data and provides an appropriatelevel of linguistic detail, and (2) a feature set thatcaptures Twitter-specific properties and exploits ex-isting resources such as tag dictionaries and ... value of 0.914. A finalsweep was made by a single annotator to correct er-rors and improve consistency of tagging decisionsacross the corpus. The released data and tools usethe output of this...
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Báo cáo khoa học: ` Inhibition of human ether a go-go potassium channels by 2+ Ca ⁄calmodulin binding to the cytosolic N- and C-termini potx
... domainsreduced inhibition of the functional channels by Ca2+⁄ CaM. Employment of CaM-EF-hand mutants showed that CaM binding to the N- and C-ter-minus are primarily dependent on EF-hand motifs 3 and ... in steps of 3) and C-terminal (amino-acids480–962 in steps of 3 and amino-acids 645–895 in steps of 2) cytosolic domains of hEAG1. Binding of BODIPY FL-labeled hCaM in the presence of 25 lmfree ... withCaM-EF-hand mutants testing for interaction with thefunctional C- and N-terminal binding sites of hEAG1channels highlighted the importance of Ca2+-bindingability of EF-hand motifs 3 and 4...
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Báo cáo khóa học: Development of recombinant inhibitors specific to human kallikrein 2 using phage-display selected substrates docx
... purification by Bradford assay and normalized by densitometry of Coo-massie Blue-stained SDS/PAGE gels [19]. Inhibition assays and stoichiometry of inhibition The stoichiometry of inhibition (SI) ... ACTs purifiedin one step by affinity chromatography. The efficiency of thebacterial recombinant system to produce active ACT wasproved by the stoichiometry of inhibition of recombinant wild-type ... excess of inhibitors ([I]o/[E]o of 100 : 1) for 30 min,hK2 is completely inhibited by rACT6.2,rACT8.3,rACT6.7 and rACT6.1,whereasrACT8.20 and rACT5.18inhibited95% and 73% of enzyme...
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Báo cáo khoa học: Inhibition of human MDA-MB-231 breast cancer cell invasion by matrix metalloproteinase 3 involves degradation of plasminogen docx
... Gulino2 and Andrew R. Mackay11Section of Molecular Pathology, Department of Experimental Medicine, University of L’Aquila, Italy;2Department of ExperimentalMedicine and Pathology, University of ... regulation of cellular fibrinolytic activity and in the down-regulation of tumour-associated angiogenesis[31–38]. Human breast tumours exhibit some of these anomalies.MMP-3 is expressed by benign and ... mean of 410 cells per filterinvaded in the presence of plasminogen.Exogenous recombinant pro-MMP-3 (0.1 and 1 lgÆmL)1) inhibited MDA-MB-231 invasion in the pres-ence of plasminogen by 24% and...
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Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
... analysis of ligand binding to C-LytA. (A) Con-formational changes induced by ligands on C-LytA monitored by near-UV CD with no ligand added (—) and upon addition of ligands:s, d, 2.5 and 20 mM ... cuvette and aprotein concentration of 19 lm. Tryptophan emissionspectra were obtained using an excitation wavelength of 280 nm, with excitation and emission slits of 3 nm, and ascan rate of 60 ... near-UV CD spectrum of C-LytA at 20 °C and pH 7.0, showing two maxima at265 nm and 290 nm. Upon addition of 20 mm choline(a saturating concentration of ligand), two minima at284 nm and 294 nm appear,...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
... The importance of the L1 loop for DNAbinding by RecA ⁄ Rad51 family proteins was observed by mutational and photocrosslinking analyses of RecA[34–37] and a mutational analysis of HsDmc1 [22].The ... binding by bacterial single strandedDNA-binding protein (SSB) and human replicationprotein A (RPA) [23,24], we performed mutationalanalyses on Tyr232 in the L1 loop and Phe279 in theL2 loop of ... HsRad51-L1 loop and measured the fluorescence changes of the tryptophanresidues upon DNA binding.ResultsStrategy of mutational analysisIn order to study the functions of the L1 and L2loops of HsRad51,...
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