Báo cáo khoa học: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells pptx
Báo cáo khoa học: " Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit"
... of MEs and the potential outcome of intercepted and non-intercepted errors.Materials and methods In April 2002, University College Hospitals London ICU intro-duced the QS 5.6 Clinical Information ... writing process resulted in either an unin-tentional significant reduction in the probability of treatmentbeing timely and effective or an unintentional significantincrease in the risk of harm when ... are given in Tables 2 and 3. Mostof the errors were minor in outcome, although two non-inter-cepted errors with CPOE led to an increased length of stay orincreased monitoring. In the first...
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Tài liệu Báo cáo khoa học: Extended half-life upon binding of destabilized intrabodies allows specific detection of antigen in mammalian cells pdf
... either the 4A- or the 7A-cotransfected cells, thus demonstrating that strong in vivo binding of the destabilized 13R4-d1-EGFP pro-teins allows them to be maintained in the cells. To rule out the ... mole-cules and the b-gal were strictly colocalized, it seemsthat the scFvs fused to d1-EGFP are maintained in the cells by binding to antigen.Generation of soluble binding-defective and cysteine-deleted ... whether the PEST signal-tagged scFv13R4 is able to bind antigen within the window of itspresence in the cells, we cotransfected COS-1 cells with the scFv-EGFP (+ ⁄ – PEST) constructs and the...
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Báo cáo khoa học: Temporal expression of heat shock genes during cold stress and recovery from chill coma in adult Drosophila melanogaster pdf
... there is littledirect evidence in the literature to confirm this link[21]. In insects, there has been a long-standing focuson Hsp70, which remains the most commonly studiedstress protein in ... crucial role in determining the distribution and abundance of animals. In insects and other ectotherms, temperature simultaneously affectsphysiological processes, biophysical structures, and metabolic ... pointsduring the cold stress and the recovery treatments (see text for further details). Control flies were kept at 25 °C and were sampled at the same time points as the treated flies.H. Colinet...
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Báo cáo khoa học: NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B–NS3 protease ppt
... werediscovered using high-throughput in vitro screening. Binding to the sub-strate-binding sites S1 and S3 is confirmed by intermolecular NOEs and comparison with the binding mode of a previously ... reported in the absence of inhibitor [4] and in the presence of peptide inhibitors [5,6] or bovine pancre-atic trypsin inhibitor (BPTI) [4]. In the absence ofinhibitor, the structure shows the b-hairpin ... because of spin-diffusion during the mix-ing time of the NOESY experiment, movements of the ligand in the binding pocket or differences in side-chain orientations between the crystal and solutionFig....
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Báo cáo khoa học: Ca2+/calmodulin-dependent kinase II signalling cascade mediates P2X7 receptor-dependent inhibition of neuritogenesis in neuroblastoma cells docx
... 21GSK3 and GSK3 a ⁄ b in N2a cells treated with 100 nM BBG for 30 and 60 min. Actin was used as a loading control and the graph represents the mean ± stan-dard deviation of the pGSK3 ⁄ actin ratio ... prominent in N2a cells [70]. The lack of CTP-mediated calcium responses alsoexcludes the presence of functional P2X4 receptors in these cells [41]. In contrast, both the substantialincrease in ... support the involvement of P2X7 receptors in the maintenance ofneuroblastoma cells in a nondifferentiated state, and point to P2X7 receptor antagonists as future potentialtherapeutic agents in the...
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Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx
... terminal cys-teine with histidine in the metallothionein a and bdomain maintains its binding capacity. Eur J Biochem259, 519–527.R. Bofill et al. C. elegans CeMT1 and CeMT2 metallothioneinsFEBS ... P17511) and CeMT2 (Uniprot P17512). The coordinat-ing and putative coordinating residues are highlighted (Cys in grey shadow, His and Tyr in bold) and the total content in each peptide is indicated. ... staining; the band with the expected size was excised and subcloned into the pGEX-4T2 vector. Before recombinant protein synthesis,all coding sequences were confirmed by automated DNAsequencing....
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Tài liệu Báo cáo khoa học:Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy doc
... with IGF-1 signaling also in C2 myoblasts overexpressing the insulin- like growth factor 1 binding protein 5 and therefore notresponding to endogenously produced insulin- like growth factor 1.Although ... IGFBP5, insulin- like growth factor 1-binding protein; IRS-1, insulin receptor substrate 1; kiAKT, kinase-inactive form of AKT;LY, LY294002; Neu2, neuraminidase 2; HS, horse serum; MAP kinase, ... is induced by postmitotic expressionof insulin- like growth factor I. Mol Cell Biol 19, 3115–3124.24 James PL, Stewart CE & Rotwein P (1996) Insulin- likegrowth factor binding protein-5...
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Tài liệu Báo cáo khoa học: Insulin-dependent phosphorylation of DPP IV in liver Evidence for a role of compartmentalized c-Src ppt
... proteinase K.DPP IV levels following stimulation with insulin and bpV(phen) In order to examine changes in DPP IV levels follow-ing insulin stimulation, rats were injected with the PTPinhibitor ... PTPinhibitor bpV(phen) 16 h and 30 min prior to insulin injection and isolation of the G ⁄ E and PM fractions.No effect on DPP IV level was detected following insulin injection. However, DPP IV ... (1989) Internalization and activation of the rat liver insulin receptor kinase in vivo.J Biol Chem 264, 12931–12940.35 Ahmad F & Goldstein BJ (1997) Functional associationbetween the insulin...
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Tài liệu Báo cáo khoa học: Insulin/protein kinase B signalling pathway upregulates metastasis-related phenotypes and molecules in H7721 human hepatocarcinoma cell line pptx
... tyrosine kinaseactivity in their intracellular domain [1]. The signalling pathway of insulin is similar to that of some other growthfactors [2], and the key signalling molecules of insulin arephosphatidylinositide-3-kinase ... arephosphatidylinositide-3-kinase (PI-3K), phosphotidylino-sitide dependent kinase-1 (PDK-1) and protein kinase B(PKB, also called Akt) [3,4]. When insulin receptor binds to insulin, its C-terminal tyrosine ... it from binding to and inhibiting the survival proteins Bcl-XL and Bcl2, or phosphorylatesIjB kinase to induce the nuclear translocation of the transcription factor NKjB for activating the survival...
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Báo cáo khoa học: Characterization of heme-binding properties of Paracoccus denitrificans Surf1 proteins doc
... proteins con-tain heme o and heme a. Assuming similar extinctioncoefficients in acetonitrile for the Soret for both heme o and heme a, we estimate 25% heme a and 75% heme o for Surf1c W200F, and ... to heme binding in either bacterial version of the Surf1 protein,with a strategic tryptophan residue possibly interactingwith the formyl group of heme a.ResultsLacking the machinery for the ... heme moiety.Interestingly, in the tryptophan to phenyalaninemutant in transmembrane helix II (W200F in Surf1c,W2009F in Surf1q), heme o is the predominant heme cofactor, indicating that this...
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