Báo cáo khoa học: Effect of oculopharyngeal muscular dystrophy-associated extension of seven alanines on the fibrillation properties of the N-terminal domain of PABPN1 pot
... The Authors Journal compilation ª 2006 FEBS 355
Effect of oculopharyngeal muscular dystrophy-associated
extension of seven alanines on the fibrillation properties
of the N-terminal domain of PABPN1
Grit ... effect on the
fibrillation properties of the most extreme disease-asso-
ciated extension of seven additional alanines, fibri...
... some
estimation about the force with which the victims were hit and
swept away by the wave.
Antiinfective therapy
Our intial choice of anti-infective therapy was a combination of
a potent quinolone combined ... [48].
Psychoemotional aftermath
With respect to the tsunami's psychoemotional aftermath, the
full impact of the wave on the mental health of the survivor...
... recommendation that further research
should study the effects of sleep deprivation and work
schedule interventions on the performance of upper-level
residents and other medical staff across a variety of
disciplines. ... assumption that the total number of days in
each schedule was the same. Under this assumption, the
observation that there were more admissions and patient-...
... Dicer knockdown on the
silencing efficacy of mismatched siRNAs
We hypothesized that the reduction in the function of
the mismatched siRNAs was a consequence of
impaired interactions with TRBP and ... essentially the same silenc-
ing capacity as in the presence of TRBP, actually
becoming the most active of all the siRNAs under these
conditions (Fig. 2A). In contrast,...
... the
closed conformation. The only other P-loop move-
ments that have been observed in PTPs are a result of
oxidation of the catalytic cysteine.
Sensitivity of PhyAsr to oxidation
The low pK
a
of the ... efficiency
of PhyAsr
To test the hypothesis that ionic strength effects the
P-loop conformation of PhyAsr, we determined the
steady-state kinetic parameters at sever...
... demonstrated the
essential role of this region in the transcription of the
Ig-b gene. Deletion of region III decreased the expres-
sion of Ig-b mRNA to 40% of the expression in prede-
letion cells ... deletion (16 kb Del) in one allele of
the Ig-b locus (Fig. 1). Introduction of the 16 kb Del
construct into DT40 ⁄ Cre cells resulted in two deletion
clones. In one...
... coefficient
of 4.7 ± 0.8.
We have also tested the effect of Gd
3+
on the lumi-
nal side of the reconstituted channel. To decrease the
possibility of the applied Gd
3+
acting on the cytoplas-
mic site of ... affinity of gadolinium on the cytoplasmic and
also on the luminal side of the channel. Although in
single channel experiments the luminal Ca
2+
co...
... under low ionic strength conditions [8,44].
However, this effect is not seen in the kinetics of the
MA/CA hydrolysis. In the high ionic strength of the
assays the dimerization is strengthened as ... PR
inhibitor therapy, soon after the appearance of one (or a
few) critical PR mutations, therefore we have characterized
the effect of single protease mutations in respon...
... translation knowledge
in order for it to be used in the real world situ-
ation. One limitation of the corpus-based trans-
lation knowledge acquisition approach is that the
techniques of translation ... Based on this obser-
vation, we take an approach of acquiring transla-
tion knowledge of domain specific named entities,
event expressions, and collocational expressions
from...
... determine the effect of
increasing the flank length on the thermodynamic
stability of formation of secondary structures. We
have used a spectroscopic method to obtain thermal
denaturation ⁄ renaturation ... the transcription start site of the c-kit
gene. The sequences shown to the left of )108 and to the right of
)87 are the flanking sequences.
A. Arora et al....