... F, Cazzola G, Consolini R, De Mattia D,Dell’Erba G et al. (2002) Clinical, immunological, andmolecular analysis in a large cohort of patients with X-linked agammaglobulinemia: an Italian multicenterstudy. ... or SYK themselves, is capable of transforming NIH-3T3 cells [70]. In addition, weand others have demonstrated that the activation andplasma membrane localization of the fusion constructare dependent ... keytyrosines that are subject to auto- and ⁄ or transphosph-orylation, and that mediate interaction with Vav,c-Cbl and the p8 5a subunit of phosphatidylinositol3-kinase, whereas the kinase domain harbors...