... locali-zation within the developing neural tube [3,62,121]. In addition, mHSF2 is associated with DNA binding in the developing brain, including cortex, striatum,olfactory bulbs and mesencephalon, ... before and after birth in mouse brains[122,124]. No HSF4 DNA-binding activity wasreported in the developing mouse brain so far. How-ever, Hsf4b is expressed in the adult mouse brain,including ... mitochondrialdysfunction, in conjunction with markedly increasedproduction of reactive oxygen species [27,34]. In line with findings in the heart and kidney [35,36], andtogether with the down-regulation...