Báo cáo khoa học: Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production ppt

Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt

... Department of Biology and Biochemistry, University of Bath, UK2 Department of Biochemistry, University of Wisconsin–Madison, USA3 Department of Chemistry, University of Wisconsin–Madison, USAIntroductionUpon ... probes are useful for both studying and controlling the functionsof enzymes and other proteins. The most useful probes have high afﬁnity for their target, along with small size and resistance to degradation. ... [11–17], and likewise form numerous hydrogenbonds with the enzyme. Pyrophosphoryl groups havefour nonbridging oxygens, providing more oppor-tunity for the formation of hydrogen bonds than is possible...

Tài liệu Báo cáo khoa học: "Names and Similarities on the Web: Fact Extraction in the Fast Lane" ppt

... (Collins and Singer, 1999), extrac-tion of binary relations (Agichtein and Gravano,2000), and acquisition of structured data for taskssuch as Question Answering (Lita and Carbonell,2004; Fleischman ... the candidate fact(more is better); and the number of seed facts ex-tracted by the same patterns (again, more is bet-ter) (Agichtein and Gravano, 2000; Thelen and Riloff, 2002; Lita and Carbonell, ... ﬁrst pass and adjusted for therelative distance to the start and end of the inﬁx.3.3 Ranking of Candidate FactsFigure 3 introduces a new scheme for assessing thequality of the candidate facts,...

Báo cáo khoa học: Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic b-islets ppt

... therefore wished to determine whether mir-9expression was regulated in vivo in pancreatic b-islets.To this end, we isolated pancreatic b-islets from micethat had been starved for 24 h and administered ... pan-creas, it is important to understand the roles of bothcis- and trans-acting factors that control its transcrip-tion. Mir-9 is encoded from three chromosomal loci,in both humans and mice, and the ... 1169Sirt1 mRNA and post-transcriptionally regulate itsexpression.Sirt1 is regulated in vivo in response to GSISSirt1 is known to affect GSIS in b-islets [17]. However,it is unclear whether...

Báo cáo khoa học: Uptake and metabolism of [3H]anandamide by rabbit platelets Lack of transporter? ppt

... into the cells is coupled to theactivity of intracellular FAAH [23,24]. FAAH is responsible for the catabolism of anandamide and it contributes toanandamide uptake by making and maintaining ... removinganandamide from the extracellular space and in metaboli-zing it as it has been suggested for other cells [16], and/ oranandamide could be a precursor for the strong agonistarachidonic acid and ... the enzyme preparations and assay conditions and the optimum pH is 8.5–10 [25,26]. The existence and secretion of a FAAH from the unicellular eucaryoteTetrahymena pyriformis, has been recently...

Báo cáo khoa học: Characterization and regulation of a bacterial sugar phosphatase of the haloalkanoate dehalogenase ppt

... 7275–7284.31 Papagianni M, Avramidis N & Filiousis G (2007) Gly-colysis and the regulation of glucose transport in Lacto-coccus lactis spp. lactis in batch and fed-batch culture.Microb Cell ... level ofgene regulation.Results and DiscussionThe araL gene in the context of the B. subtilisgenome and in silico analysis of AraLThe araL gene is the fourth cistron of the transcrip-tional ... enzymes dis-played in this alignment show activity to overlappingsugar phosphates [13,21] and it is tempting to speculatethat this is related to similarities in the cap domain.On the other hand,...

Báo cáo khoa học: Isolation and characterization of a D-cysteine desulfhydrase protein from Arabidopsis thaliana pptx

... 4C).Expression studies on the RNA and protein levels and enzyme activitiesArabidopsis plants were grown in the greenhouse for 10–45 days and all plant tissue above ground was used for the analyses. The ... is well documented that, in general, amino acids areused in the l-form, and enzymes involved in theirmetabolism are stereospeciﬁc for the l-enantiomers.However, d-amino acids are widely distributed ... protein standard. The DNA and amino acidsequence analyses and prediction of the molecular masseswere performed with the programs mapdraw and proteanin dnastar (Lasergene, DNASTAR, Madison, WI,...

Báo cáo khoa học: Neuroglobin and cytoglobin expression in mice Evidence for a correlation with reactive oxygen species scavenging doc

... upon 48 h of hypoxia, and that thisincrease is dependent on the tissue and the severity ofhypoxia. The mechanism of induction of Cygb is regu-lated by HIF-1. The aim of this study was to illustratethe ... Belgium) and Taq-Man Gene expression assays (Applied Biosystems) for Ngb,Cygb and HIF-1a. The parameters for PCR ampliﬁcationwere 50 °C for 2 min, 95 °C for 10 min, and by 40 cyclesof 95 °C for ... neuronal (brain and retina) and some endocrine tissues, whereas Cygb is detected in the nucleus and in the cytoplasm of manytypes of tissue [2,3]. In response to hypoxia, Ngb is up-regulated...

Báo cáo khoa học: Cloning and functional analysis of 5¢-upstream region of the Pokemon gene pptx

... distance between the two E-boxes abol-ished synergistic activation. Therefore, the synergisticaction required the presence of two E-boxes separatedby an appropriate distance in a looped form, ... cellular transformation and induced cell senescence and apoptosis [22,26]. There-fore, Pokemon plays a crucial role in cell tumorigenesis and may be a potential therapeutic target for humancancer ... tramtrack and bric-a-brac [1]. It is  120 amino acids long and usu-ally exists in a few transcriptional repression complexes[2]. The POZ domain is highly conserved from yeast tohumans, and is involved...

Báo cáo khoa học: "A Re-examination of Machine Learning Approaches for Sentence-Level MT Evaluation" ppt

... METEOR(Banerjee and Lavie, 2005) and GTM (Melamed etal., 2003) calculate both recall and precision; ME-TEOR is also similar to SIA (Liu and Gildea, 2006)in that word class information is used. Finally, ... ﬂuency and adequacy scores. The full dataset (6 × 919 = 5514instances) is split into sets of training, heldout and test data. Heldout data is used for parameter tuning(i.e., the slack variable and ... of good translations is much smaller, and is where all the systems are aiming for; thus, assess-ments of sentences from a good system can be muchmore informative.4.4 DiscussionExperimental...

Báo cáo khoa học: A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis doc

... expression is in tissues and embryos and induced by oxidative stress. (A) Ten micrograms of total RNA isolated from brain,heart, spleen, liver, kidney, stomach, muscle, testis, lung and fat tissues ... Winge DR, Johnson MK & Outten CE (2011)Histidine 103 in Fra2 is an iron–sulfur cluster ligand inthe [2Fe–2S] Fra2–Grx3 complex and is required for in vivo iron signaling in yeast. J Biol ... are peer-reviewed and may be re-organized for online delivery, but are notcopy-edited or typeset. Technical support issues arisingfrom supporting information (other than missing ﬁles)should...

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