Báo cáo khoa học: The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction pptx
Báo cáo khoa học: The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction pptx
... in the product chain length determination mechanism of type II GGPS. Moreover, this result suggests that the other subunit of the homooligomeric enzyme isinvolved in the product chain length determination mechanism. ... information on the product determination mecha-nism of type II GGPS. (A) The direction of the geranylgeranyl chain of GGPP bound in a subunit (blue) of S. alba GGPS. The x-end of the chain touches ... contribute to the prod-uct determination mechanism of type II GGPS.Mutation at the second position upstream from the G(Q/E) motifBecause the mechanism of chain length determination for type II GGPS...
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Tài liệu Báo cáo khoa học: ˚ The 1.8 A crystal structure of a proteinase K-like enzyme from a psychrotroph Serratia species docx
... similararrangement, and the side chain of Ser97 in VPRK istoo short. One side of the loop is involved in the bind-ing of the P2–P4 residues of a substrate. The other side of the loop is close to Arg94 ... considered to display differences in the fold of the main chains. None of these includes any of the binding sites, but some are located in the vicinity.Three of the regions with different conformationinvolve ... samepositions as the Capositions of the inhibitors. Intro-duction of the tripeptide causes a slight rotation of Ser224, such that the hydroxyl group of the side chain weakens its catalytic triad interaction...
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Tài liệu Báo cáo khóa học: The PAS fold A redefinition of the PAS domain based upon structural prediction ppt
... Toovercome the fact that the prosa z-score is dependant of the length of the amino acid sequence, the z-score wasnormalized using the natural logarithm of the sequence length [39]. The resulting ... distribution of the percentage best model, for each of the 672 best models, is presented in the left panel. Of the six template structures used, 54% of the sequencesgive the best model with the FixL ... that region of the PAS fold that is part of the region which tethers the PAS Table 4. Backbone root mean square deviation values (in A˚ngstrom) of the structural alignment of the six representative...
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Báo cáo khoa học: The N-terminal hybrid binding domain of RNase HI from Thermotoga maritima is important for substrate binding and Mg2+-dependent activity pot
... changed either in the presence orabsence of the metal cofactor. By contrast, the sub-strate binding affinity of the RNase H domain proba-bly increases in the presence of the metal cofactorcompared ... sequences of the oligonucleotides cleavedby the enzyme are shown. The differences in the lengths of the arrows reflect relative cleavage intensities at the position indicated. Theselengths do ... respectively. The resultantDNA fragments were digested with NdeI and HindIII orEcoRI, and ligated into the NdeI-HindIII or NdeI-EcoRIsites of pET25b. The pET25b derivative for overproduction of Tma-W22A...
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Tài liệu Báo cáo khoa học: Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases ppt
... Mechanism of product chain length determination and the role of a flexible loopin Escherichia coli undecaprenyl-pyrophosphate synthase catalysis. J Biol Chem 276, 47474–47482. Product chain length of ... the length of prenyl products, indicating a requirement forinsertion of specific amino acid residues for lengthen-ing the ultimate product chain. Moreover, this sugges-ted the significance of ... of the ultimate product chain length, and proposed amodel for chain- length determination. Further elucida-tion and manipulation of chain- length determination mechanisms of cis-prenyltransferase...
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Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx
... G4and the sidechain of Asn122. In the second model(Fig. 1B) the structure of the hexanucelotide is, on the whole, unchanged and the majority of the interactions thatwere seen in the first ... attributed solely to the change incharge and size of the sidechain of this single residue, the crystal structure of RTA N122A was solved. The RMSDfrom the Caatoms of the wild -type RTA crystal ... red. C1 of the hexanucleotide is at the bottom left and the target adenineis at the top of each model. The sidechains of RTA are shown in blue. (A) Model 1 has the tetraloop bound in the active...
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Tài liệu Báo cáo khoa học: Electron transfer chain reaction of the extracellular flavocytochrome cellobiose dehydrogenase from the basidiomycete Phanerochaete chrysosporium doc
... of propionates of heme, was mutated to Tyr,and the thermodynamic and kinetic properties of the mutant (F166Y) werecompared with those of the wild -type (WT) enzyme. The mid-pointpotential of ... because of the weaker domain interaction of this mutant enzyme. The F166Y mutant is, however,useful for monitoring the electron transfer step of CDH, because the mutation affects only the electrontransfer ... full understanding of the redox reaction of CDH, the reduction mechanism of the electron accep-tor should be clarified. However, several groups haveproposed two possible mechanisms for this...
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Tài liệu Báo cáo khoa học: The resident endoplasmic reticulum protein, BAP31, associates with c-actin and myosin B heavy chain Analysis by capillary liquid chromatography microelectrospray tandem MS ppt
... loss of these interactions even though the amounts of cellularcrBAP31 and c-actin did not apparently change (Fig. 5B).These findings, coupled with the strong enrichment of the c-isoform of actin ... have arisen at the genetic level (by the presence of two or more allelic copies of the gene of interest) rather than by the presence of low-levelamount of contaminating proteins in the immunocomplex.In ... andhetero-dimerization of proteins, and these sequences mayfacilitate the specific interactions between BAP31 andmyosin heavy chain. Furthermore, the initial stage of cytoplasmic apoptosis ) the release of extracellular...
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Báo cáo khoa học: " Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit"
... During the monitoring period, details of the total number of all prescribed drugs on each day wererecorded.MEs were assessed by type and patient outcome. The type of error was categorised by the ... (where the patient received the drug). The intercepted errors were scored separately on the basis of their possible impact on the patient, if the prescriptionhad been administered as prescribed. The ... once in the proportion of error analysis. This explains why the total of hand-written prescribing (HWP) error types stated here is in excess of the total number of errors stated in the results...
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Báo cáo khoa học: "The clinical value of daily routine chest radiographs in a mixed medical–surgical intensive care unit is low"
... intravenouslines). The observers were not involved in the daily care of the patients, and ICU physicians were not aware of this part of the observation. As a consequence, the clinical relevance of the predefined ... for other infections, and the absence of radiological signs of pulmonary congestion mighthave resulted in another fluid therapy regimen.We did not score for the clinical relevance of the unexpectedpresence ... determine the inci-dence of major abnormalities on daily routine CXRs and theirimpact on management of ICU patients.Materials and methodsData on all daily routine CXRs ordered at the ICU of the...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018chuyên đề điện xoay chiều theo dạngNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDETrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngBT Tieng anh 6 UNIT 2Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ