Báo cáo khoa học: Lipopolyamine treatment increases the efﬁcacy of intoxication with saporin and an anticancer saporin conjugate doc

... is an anticancer toxin that consists of a chemical conjugate between the human uPA and native saporin. Both saporin and uPA -saporin enter the target cell by endo-cytosis and must then escape the ... Unfortunately, saporin passage into the cytosol remains a poorly understood process.Both saporin and anticancer saporin conjugatesenter the target cell by endocytosis and then escape the endomembrane ... the efﬁcacy of intoxication with saporin and an anticancer saporin conjugate Sandra E. Geden1, Richard A. Gardner2, M. Serena Fabbrini3, Masato Ohashi4, Otto Phanstiel IV2 and Ken Teter11...

Báo cáo khoa học: "Medical treatment for the terminally ill: the ‘risk of unacceptable badness’"

... meaningful chance of reanimation [8].Some reasons why this occurs are as follows:1. Physicians tell surrogates that they can make any decisionthey want as an open-ended ideal. This puts them ... suspended animation; they arenot alive in the sense the we enjoy life but neither are theyable to die as long as nutrition, hydration, ventilation, and perfusion are assured. In many cases reanimation ... when the benefitappears to outweigh the risk and when there is a reasonablechance for an outcome that the patient would desire. Itfrequently seems reasonable to buy sufficient time to seewhether...

Báo cáo khoa học: Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down-regulating ﬁbrinolysis doc

... similar Kmvalues of the native and WT, and the YQ mutant CPU with a synthetic and physiologicalsubstrate of CPU. There seem to be no major changesin the positioning of the propeptide, as ... on the basis of their model of humanCPU, that the two consecutive I at positions 204 and 205 are exposed to the surface, and because they arequite unique to CPU, might be of importance for the process ... tocreate the mutants YQ and YP, and the T1⁄ 2 of theiractivity was determined (Table 2). These combinationsincreased the stability of CPU’s activity, especially the YQ mutant.Following the ﬁrst...

Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx

... fragment accompanied by the appear-ance and an increase in the 80 kDa fragment (Fig. 2).Although both the untransfected cells and the cellstransfected with the vector alone started to show the 80 ... approved by the InstitutionalAnimal Care and Use Committee of the Center South Uni-versity, and were carried out in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory ... cells transfected with the control oligo-mers and much lower at 13 and 44% in cells transfect-ed with the nucleolin ⁄ C23 antisense oligomer(Fig. 6C). Second, the activity of caspase-3 was analy-sed...

Tài liệu Báo cáo khoa học: Nuclear receptors in the mosquito Aedes aegypti Annotation, hormonal regulation and expression proﬁling ppt

... included a DNase I treatment, and cDNA synthesizedas described above. The time points analyzed were 1–2 and 4–5 days pre-vitellogenesis, and 6, 12, 24, 36, 48 and 72 hPBM. To standardize qPCR inputs, ... deaths annually (http://www.who.org) and dengue, a rapidly expanding disease in most tropical and subtropical areas of the world, has become the most signiﬁcant arboviral disease of humans. Anophe-line ... development of the mostanterior region of the brain [99,100]. Tlx, the verte-brate ortholog of Tll, is required for the correct devel-opment of the visual system and neurogenesis[101,102]. The expression...

Tài liệu Báo cáo khoa học: Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I pdf

... on SDS ⁄ PAGE. Lanes a and d, in the absence of both TnC and Ca2+; lanes b and e, in the presence of TnC and the absence of Ca2+; lanes c and f, in the presence of bothTnC and Ca2+. Ac, ... ATnI130)252, and ATnI232)292did not migrate into the gels, while free ATnI-52K and ATnI1)128exhibited a band near the origin and at the middle of the gel, respectively. The bands corresponding to the ... run in the absence (lanes h–l) or presence (lanes m–q) of equimolar amounts of Akazara scallop TnC. Lanes h and m, ATnI-52K; lanesi and n, ATnI-19K; lanes j and o, ATnI1)128; lanes k and p,...

Tài liệu Báo cáo khoa học: "Event Matching Using the Transitive Closure of Dependency Relations" pdf

... Es, with dx.d de-noting the index of the word that is the descendantin dx and dx.a denoting the ancestor. We deﬁne the following matching function to match the pair of de-scendants (or ancestors):matchd(de, ... deﬁned analogously for ancestors.That is, matchd(de, ds) returns true if the morph of the descendant of deis the same as the morph of the descendant of ds, or if both descendants havecanonical ... Ee and Es, the descendant -of relation of the event descrip-tion e and the sentence s, respectively. We use the following, two-tiered strategy.Let de, dsbe elements of Ee and Es,...

Báo cáo khoa học: Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding pdf

... interaction between ClpS and the N-domain of RR ⁄ AA, and this result suggests that neither the local nor the overall structure of the RR ⁄ AA mutantwas compromised.Mutation of the conserved arginine ... Error bars represent the standard error of the mean. A non-speciﬁcprotein band is indicated by an asterisk. (D) The functional interaction between ClpS and ClpA (wild-type and RR ⁄ AA) was observed ... gel ﬁltration without the addition of ATP (white bar, lane 1),in the presence of 160 pmol dWB ClpA6without (lane 2) or with addition of 2 mM ATP (lane 3), or in the presence of 160 pmol RR...

Báo cáo khoa học: "Some Problems in the Mechanical Translation of German" pdf

... be the subject of the clause. This ap- plies to about half of all the instances where the function of the relative pronoun is ambiguous. 2. On the other hand, if the form of the sub- stantive ... identical to the ac- cusative in the feminine singular of der and welcher, in the neuter singular of der, welcher and was, and in the plural (all genders) of der and welcher. The first two ... denoted as the feminine dative, since no preposition is constructed with the nominative case. On the other hand, * Now at the University of Manchester, Man- chester, England. without a...

... only the part -of- speech tags and grammarinformation are considered. The left hand side of the ﬁgure shows the original structure of the sen-tence, and the right hand side shows the trans-formed ... and reduce the number of levels in the hierarchy.This paper considers the tasks of identifying the syntactic structure of text chunking and gram-mar parsing with previously annotated text doc- uments. ... involves analysing the results over two sets of data. The ﬁrst is a selection of data from CoNLL-2004 and contains 8936 sentences. The seconddataset is part of the Lancaster Treebank corpusand...

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