Báo cáo khoa học: Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin pptx
Báo cáo khoa học: Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin pptx
... al. Formation of amyloid beta oligomers by prefoldin FEBS Journal 275 (2008) 5982–5993 ª 2008 The Authors Journal compilation ª 2008 FEBS 5993 Formation of highly toxic soluble amyloid beta oligomers by ... Modulation of neurodegeneration by molecular chaperones. Nat RevNeurosci 6, 11–22.M. Sakono et al. Formation of amyloid beta oligomers by prefoldin FEBS Journal 275 (2008) 5982–5993 ª 2008 The Authors ... observed. On the other hand,when Ab was incubated with PFD, high -molecular- mass Ab oligomers with a broad range of molecular M. Sakono et al. Formation of amyloid beta oligomers by prefoldin FEBS...
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Báo cáo khoa học: Pulchellin, a highly toxic type 2 ribosome-inactivating protein from Abrus pulchellus Cloning, heterologous expression of A-chain and structural studies ppt
... The rPAB showed anapparent molecular mass of 60 kDa, similar to the native pulchellin. The toxic activities of the rPAB and native pulchellin were compared by intra-peritoneal injection of ... RIPs due totheir potential role in the development of therapeuticagents. Perhaps the most promising approach to apply-ing RIPs in therapy is the use of immunotoxins inwhich the toxic A-chain ... spectroscopy. The cloning process will enable the production of soluble and active homogeneous protein, which isdesirable to the study of its use in immunotherapy.Comparison of the primary sequences of...
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Báo cáo khoa học: A new highly toxic protein isolated from the death cap Amanita phalloides is an L-amino acid oxidase pdf
... comparing the in silicotryptic digest of the translated amino acid sequencewith the list of masses of tryptic peptides obtained by the MALDI-TOF analysis. In total, nine peptides from the list of ... translation is under the secondnucleotide of the corresponding codon. The masses of underlined peptides correspondto the masses of tryptic peptides (Table S2)identified by MALDI-TOF MS.CytotoxicL-amino ... cal-culated from amino acid composition of the sequencedpeptides amounted to the values of the correspondingpeptides obtained by the MALDI-TOF MS. Directsequencing of the toxophallin N-terminus from...
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Báo cáo khoa học: Formation of nucleoprotein RecA filament on single-stranded DNA Analysis by stepwise increase in ligand complexity potx
... possible in part by grants from the Program of Basic research of the Presidium of RAS ‘Presidium of the Russian Academy of Sciences (Molecular and Cell Biology Program 10.5)’, from the Russian Foundation ... withRecA under the condition used (data not shown), and the best of them d(pT)20was used for the rest of the study. At the RecA monomer: ODN ratio of 10 : 1,almost all d(pT)20was in the filament, ... to the ratio of apparent I50values for theseinhibitors, I50(2) ⁄ I50(1), and the ratio of these valuesgives the Kdvalue characterizing a difference of the enzyme contacts between the...
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Tài liệu Báo cáo khoa học: Proteolysis of Pseudomonas exotoxin A within hepatic endosomes by cathepsins B and D produces fragments displaying in vitro ADP-ribosylating and apoptotic effects doc
... apoptotic effect).Both pathways require the translocation of ETA into the cytoplasm of toxin-treated cells. On the basis of the reconstitution of the cytotoxic pathways within vitro cytosol and ... EF-2 on the one hand, and the mitochondrialmembrane on the other hand. However, the potentialrole (if any) of ADP-ribosylation of EF-2 in the mitochondrial apoptotic response induced by the toxin ... proteasecathepsin D, as indicated by the following observa-tions: (a) the inhibitor profile of the endosomalETA-degrading activity was very similar to that of cathepsins B and D [30]; and (b) the...
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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt
... numbers over the diagrams indicate the position of the corresponding nucleotides relative to the translation start site, and the numbersin parentheses below the diagram show the position of the corresponding ... of pGL3–basic vector andwas half that of pGL3–promoter vector. These findingsdemonstrate the promoter activity of the 5¢-flankingregion of exon 1 in DNASE1. Deletion of the upstream end of the ... software as the cycle number atwhich the fluorescence of the reporter dye crossed the threshold in log-linear range of PCR. The copy numbers of the respective DNASE1 cDNA were quantified by interpo-lating...
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Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
... homology 1 domain of all Smads binds to importin-b in the case of Smad3and importin-a in the case of Smad4, while mutation of the NLS blocks the ability of these proteins to enter the nucleus [95–98]. ... Smad trafficking – the role of the Ran GTPaseMost current evidence on the mechanisms that govern the dynamic shuttling of Smad proteins in the cell isbased on the behavior of engineered GFP–Smad2 ... complexity anddepth of understanding of TGFb signaling increase, amost critical aspect of the whole signaling pathwayremains the sequence of specific steps and the establishment of the complete time-lapse...
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Báo cáo khoa học: Transthyretin and familial amyloidotic polyneuropathy Recent progress in understanding the molecular mechanism of neurodegeneration pdf
... increase the concentrations of the more toxic low -molecular- mass species. If the amyloid deposits are less toxic than the oligomeric TTR species, decreasing the concentra-tion of the amyloid ... the concentration of the oligomeric specieswere also decreased.Mechanism of neurotoxicity in FAP: the lesson from other amyloidosesA number of studies have examined the mechanism of neurotoxicity ... that the distribu-tion of TTR deposition reflects the presence of theseendogenous factors. In the case of the Ab protein of Alzheimer’s disease, a number of proteins and factors(pathological chaperones),...
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Báo cáo khoa học: Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines docx
... cDNA of LEPRb,phosphorylation of STAT1, STAT3, STAT5 and the ERK kinases was induced by leptin. The weakresponse of STAT5 to leptin compared to that elicited by GH can be partially explained by ... partially explained by the rather ineffec-tive transfection of the HIT-T15 cells (estimated at10–20% of transfected cells). Cells expressing the shortsplice variant of the leptin receptor (LEPRa) ... indicatingthat essential components of the AMPK pathway werepresent in these cell lines.Role of the intracellular tyrosine residuesin LEPRbTo determine the role of the three intracellular tyrosineresidues...
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Báo cáo khoa học: Optimization of P1–P3 groups in symmetric and asymmetric HIV-1 protease inhibitors pptx
... over the active site. They undergo structuralchanges on binding of the inhibitor molecule. In the unliganded protease structure, the conformation of the flaps is open, thereby exposing the active ... conser-vative and limited. The binding capacity of the S3/S3¢ siteswas exploited by elongation of the compounds with groupsin the P3/P3¢ positions or by extension of the P1/P1¢ groups.Furthermore, water ... arrangement, the twofold symmetry axis of the inhibitorwill not coincide with the protease twofold axis. Despite the ability of the protease to adapt to differences in the size of the inhibitor side...
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