Báo cáo khoa học: Post-ischemic brain damage: pathophysiology and role of inﬂammatory mediators ppt

... pathophysiology and role of inflammatory mediators Diana Amantea1, Giuseppe Nappi2, Giorgio Bernardi3, Giacinto Bagetta1,4 and Maria T. Corasaniti51 Department of Pharmacobiology, University of Calabria, ... 2008)doi:10.1111/j.1742-4658.2008.06766.xNeuroinflammatory mediators play a crucial role in the pathophysiology of brain ischemia, exerting either deleterious effects on the progression of tis-sue damage or beneficial roles during ... Excellence in Brain Research and Department of Neuroscience, ‘‘Tor Vergata’’ University, Rome,Italy4 University Centre for Adaptive Disorders and Headache, Section of Neuropharmacology of Normal and...

Báo cáo khoa học: Mycobacterium tuberculosis ClpC1 Characterization and role of the N-terminal domain in its function ppt

... Construction and puriﬁcation of M. tuberculosis ClpC1 and its deletion mutants. (A) SDS ⁄ PAGE of puriﬁed full-length ClpC1 and deletion mutants, ClpC1D1 and ClpC1D2. (B) Full-length ClpC1 and deletion ... beenannotated. Bearing in mind the importance of the Clpfamily of proteins in survival and virulence, it is of interest to understand the mode of action of theseproteins in M. tuberculosis.In this ... in its pathogenesis and an understanding of their mode of action could be useful in exploring themas drug targets.ResultsFigure 1 shows the sequence and putative domains of M. tuberculosis...

Tài liệu Báo cáo khoa học: Complete subunit sequences, structure and evolution of the 6 · 6-mer hemocyanin from the common house centipede, Scutigera coleoptrata pptx

... submitted to MALDI-TOF analysis and assigned to distinct subunits.Fig. 1. SDS/PAGE and immunoblotting of S. coleoptrata hemocyanin.About 10 lg of total hemolymph protein (HL) and 3 lgofpuriﬁedhemocyanin ... composed of 12 HcA, 12 HcB, six HcC and six HcD polypeptides. Thus the basic building block of the hemocyanin, the hexamer, most likely contains twocopies of each HcA and HcB, and single copies of ... SDS/PAGE and stained by Coomassie brilliant blue. The twohemocyanin bands were cut out and dispersed. About100 lg of hemocyanin was used for the immunization of rabbits. For determination of the...

Tài liệu Báo cáo khoa học: "Hypertext Authoring for Linking Relevant Segments of Related Instruction Manuals" pptx

... where cw and cw' are scores of importance for co- occurrence of words, tk and t~. Intuitively, cw and cw' are counter parts of tf. idf for co-occurrence of words and co-occurrence ... evaluation of our proposed methods with recall and precision defined as follows. recall = ~ of retrieved pairs of relevant segments precision= of pairs of relevant segments of retrieved pairs of ... 200 pairs of segments by hand, actually by two students in the engineering department of our university to extract pairs of relevant segments. The guideline of selection of pairs of relevant...

Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

... presence of these amino acids and amino acid derivatives, and values of DGD°, measuredin triplicate, are given in Table 1.The effect of polyols on the kinetic parameters (Km and kcat) of the ... properties and the reaction of the freeenzyme and free substrate [29]. We have therefore esti-mated kcat⁄ Kmvalues of all the reactions in the pres-ence and absence of all classes of osmolytes. ... advances in understanding theeffect of osmolytes on protein stability, folding and theactivity of proteins and enzymes, the relationshipbetween protein stabilization by osmolytes and its con-sequent...

Báo cáo khoa học: "Multimodal Menu-based Dialogue with Speech Cursor in DICO II+" pptx

... can hear whatthe user says, understands the words that are spoken(semantic understanding), understands the meaning of the utterance (pragmatic understanding) and ac-cepts the dialogue moves performed ... University of Gothenburg.Dico II+ was implemented by the authors, FredrikKronlid, Peter Ljungl¨ of and Andreas Wiberg. Theauthors gratefully acknowledge the assistance of Volvo Technology AB and ... ﬂexible dialogue capabilities of the GoDiS dia-logue manager, and the concept of MMD, we believethat a Speech Cursor provides a powerful and user-friendly way of interacting with menu-based...

Báo cáo khoa học: "Linguistically Motivated Features for Enhanced Back-of-the-Book Indexing" ppt

... training and evaluation purposes, we used arandom split of the collection into 90% training and 10% test. This yields a training corpus of 259 docu-ments and a test data set of 30 documents.2.2 Candidate ... based on an ensemble of syntac-tic, discourse-based and information-theoretic prop-erties of the candidate concepts. In experiments per-formed on a collection of books and their indexes,the ... the932level of each candidate index entry. Starting with aset of candidate entries, the algorithm automaticallydecides which entries should be added to the back- of- the-book index, based on a set of...

Báo cáo khoa học: "A RULE-BASED APPROACH TO EVALUATING IMPORTANCE IN DESCRIPTIVE TEXTS" pptx

... phase includes the understanding of the literal meaning of each sentence in the text, the appropriate representation of time relations, and the treatment of quantification and reference. The structure ... aspects of the understanding activity, that defines the motivations and objectives that are behind the reading process. The role of the goal is twofold: exerting control on the activation of importance ... 1981), and it seems to require different understanding processes, different summarization skills, and different cognitive models (Lehnert, 1984). Work on the problem of understanding and summarizing...

Báo cáo khoa học: Structural origins for selectivity and speciﬁcity in an engineered bacterial repressor–inducer pair pdf

... with the coordinates of the ligand-free struc-ture. Reﬁnement of the complex converged at an Rwork of 20.7% and an Rfreevalue of 26.1%. The ligand 4-ddma-atc and ligand restraints parameters ... positioning of the ligands and the conformations of the residues lining the bindingsite (Table 2). In an initial comparison of the ligandpositions of tetracycline, dox and atc in TetR, theseligands ... reso-lutions of 2.1 A˚. Analysis of the structures in light of the available bindingdata and previously reported TetR complexes allows for a dissection of theorigins of selectivity and speciﬁcity....

Báo cáo khoa học: Photosynthetic acclimation: State transitions and adjustment of photosystem stoichiometry – functional relationships between short-term and long-term light quality acclimation in plants ppt

... the surroundings of Jena). The range of photosynthetically activeradiation (400–700 nm) and the absorption maxima of PSII and PSI(680 and 700 nm) are marked along the top of the ﬁgure. Condi-tion ... appear-ance of clouds and the leaf movement by wind. Bioticinﬂuences depend mainly on the individual position of a plant within an ecosystem, the density of the plantstand or, in case of algae, ... expression of photosystem genes and in the accumulation of Chl a and Chl b [29]. Despite the differences in the timescales of action, the LTR-like state transitions are triggeredby the redox state of...

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