Báo cáo khoa học: Increased susceptibility of b-glucosidase from the hyperthermophile Pyrococcus furiosus to thermal inactivation at higher pressures pptx

... Increased susceptibility of b-glucosidase from the hyperthermophile Pyrococcus furiosus to thermal inactivation at higher pressures Marieke E. Bruins1, Filip ... be a cause of inactivation at higher pressures. No dissociation intosubunits was observed. One similar example from the literature showed that inactivation of the dimericalmond b-glucosidase ... result of unfolding,dissociation or aggregation of the intact enzyme [16].Inﬂuence of temperature on enzyme inactivation by pressure treatment The inﬂuence of temperature on the inactivation of pressure-treated...

Báo cáo khoa học: Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis pot

... Whereas the amounts of total and phosphory-lated c-Fos increased in the presence of ATZ + mer-captosuccinic acid, there was no change in the levels of total and phosphorylated c-Jun throughout the ... LMW-PTP [13]. The cysteines in the active sites of these phosphatasesare easily inactivated by ROS, resulting in activation of the ERK pathway [14]. However, factors that acton the mitochondria ... bandswere then quantiﬁed and expressed as the fold change from the density of untreated hepatocytes as determined by densitometry (Ab,c). The values are the means ± SE of ﬁve separate experiments. The...

Báo cáo khoa học: Differential susceptibility of Plasmodium falciparum versus yeast and mammalian enolases to dissociation into active monomers doc

... conformational states of the monomeric form of the enolase. A schematic representation of the dissoci-ation and association of r-Pfen is presented inScheme 1, where Mntis the native monomer, ... representation of dissociation of the dimeric(D) form of enolase to the imidazole-induced and pH-induced mono-meric (Mimor MpH) forms. The dimer is shown to dissociate into the native form ... in r-Pfen) involving two glutamate residues.pH-induced dissociation of the enzyme may arise due to protonation of the side chains of these glutamateresidues at low pH (pKa 4.5–5.5).Although...

Báo cáo khoa học: Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa ⁄ fa rats pptx

... thanhepatocytes from 11–13-week-old male rats.Expression of glycogen-targeting proteins inhepatocytes from fa ⁄ fa rats To test whether the defect in hepatocytes from fa ⁄ farats is associated ... phosphorylase-aand glycogen synthesis in hepatocytes from fa⁄ fa rats by modulating the concentration of phosphorylase-a. Treatment of hepatocytes from fa ⁄ farats and Fa ⁄ ? controls with a ... of either GLor PTG in hepatocytes from fa ⁄ farats. However, we demonstrate that expression of R6protein is markedly decreased in hepatocytes from fa ⁄ fa rats. To our knowledge this is the...

Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-afﬁnity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt

... details of these signaling events have yet to beinvestigated, many of the molecular interactions down-stream of the Eph and ephrin molecules appear to lead to the regulation of the cytoskeleton of ... recently, the Src family kinases (SFKs) and the PTP-BL phosphatasewere proposed to be mediators of the phosphorylation state of the cytoplasmic domain of ephrin B1 whereby the SFKsmay create the ... unknown whether the two classes of eﬀectors can bind to B ephrins simulta-neously or if the binding of one aﬀects the binding of the other. We report here that phosphorylation of Tyr304 in the functional...

Tài liệu Báo cáo khoa học: ATPase activity of magnesium chelatase subunit I is required to maintain subunit D in vivo ppt

... function of the instability of the 70 kDa subunit. Obviously, the D subunit is a substrate of the I subunit, which led to questions concerning the assembly of the I and D building blocks into the ... studies of deuteroporphyrin IX to the H-subunit show a Kdvalue of 0.53–1.2 lM[5]. The large subunit has therefore been suggested to be the catalyticsubunit. The exact role of the other two ... accord-ing to Novagen. All buffers used for the puriﬁcation of the XAN-G polypeptide had to contain 6Murea to prevent the protein from precipitation. The proteins were desaltedinto 10 mMNa-phosphate...

Tài liệu Báo cáo khoa học: Quantitative estimation of channeling from early glycolytic intermediates to CO2 in intact Escherichia coli pdf

... glycolysis, the TCA cycle, the oxidative limb of the pentose phos-phate pathway (OPPP), the urea cycle. However, theseinvestigations do not provide data that can be used to calculate the fraction of the ... Alsothese data by themselves do not allow us to calculate the fraction of the ﬂux that is channeled. The ﬁrstadditional requirement is to show that the exogenousintermediate from the incubation ... cell.Saturation of 14CO2evolution rate by the mutantstrain as a function of concentration depended on sub-strate. The rate of 14CO2evolution was saturated when the concentration of glucose...

Tài liệu Báo cáo khoa học: "Structural Definition of Affixes from Multisyllable Words" docx

... unwise to eliminate them at this point in the research. What is indicated, perhaps, is the structural classification of the weak suffixes by degree of weakness as a means of approaching the suffix-in- ... all the affixes could not be ex- pected to show up in two-vowel-string words. This paper summarizes the results of applying a modified form of the operational definition to data consisting of ... subject each of the weak suffixes to a qualifying test, namely, that in the two-sylla- ble data set there not be two sets of illegal strings preceding the suffix, where each set had at least...

Tài liệu Báo cáo khoa học: Allosteric modulation of myristate and Mn(III)heme binding to human serum albumin Optical and NMR spectroscopy characterization pptx

... FEBSreach saturation for HSA concentrations well lowerthan in the absence of myristate. This indicates thatbinding of myristate to the modulatory site also increa-ses the afﬁnity of Mn(III)heme ... coordinated to the metal ion or bound to the protein in close proximity of the paramagnetic center the dipolar interaction is modu-lated by the reorientation of the macromolecule withrespect to the ... bysubtracting the width of the H217O signal in the presence of HSA from the width of the H217O signal in the presence of Mn(III)heme–HSA at different myristate con-centrations. DW values are related...

Báo cáo khoa học: Identiﬁcation of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells ppt

... BP800, Helsinki, Finland). The growth rate was cal-culated as the ratio of the absorbance of the experimentalwell to that of a blank well, and the IC50 was also calculated.Hoechst stainCells ... medulloblastoma cells, perhaps because of the methylation of the promoter, and restoration of DKK1expression can induce apoptosis and suppress colonyformation [42]. As a suppressor of cancer, the ... chemotherapy of ton-gue cancer, but the effectiveness of monotherapy withPYM for preoperative chemotherapy is only about67% [5,6]. Moreover, the therapeutic beneﬁts of che-motherapy can be attenuated...

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