... hypophos-phatasia, (c) childhood hypophosphatasia, (d) adulthypophosphatasia and (e) odonto hypophosphatasia[1–4]. Perinatal and infantile forms of hypophosphata-sia are severe and are usually transmitted ... alkalinephosphatase with missense mutations causinghypophosphatasia. Eur J Med Genet 50, 367–378.28 Cai G, Michigami T, Yamamoto T, Yasui N, StomuraK, Yamagata M, Shima M, Nakajima S, Mushiake S,Okada ... M, Amizuka N, Hoshi K, Ozawa H, KumagaiH, Omura S, Misumi Y, Ikehara Y & Oda K (1998)Intracellular retention and degradation of tissue-nonspe-cific alkaline phosphatase with a Gly317fi Asp...