Báo cáo khoa học: BRCA1 16 years later: nuclear import and export processes doc

... 501 and 507 was vital for BRCA1 nuclear import. Although these data indicated that BRCA1 enteredthe nucleus via a basic arginine-lysine-rich nuclear M. E. Thompson BRCA1 nuclear import and export FEBS ... 719–736.30 Yang ES & Xia F (2010) BRCA1 16 years later: DNAdamage-induced BRCA1 shuttling. FEBS J 277, 3079–3085.M. E. Thompson BRCA1 nuclear import and export FEBS Journal 277 (2010) 3072–3078 ... BRCA1. Nuclear targeting sequences of BRCA1 are shownin relationship to the RING ﬁnger domain, BRCA1 C Terminus (BRCT) and transcriptional activation domains. BRCA1 αβ BRCA1 αβ BRCA1 αβ BRCA1 αβ BRCA1 α BRCA1 αβαα BRCA1 BARD...

Báo cáo khoa học: BRCA1 16 years later: DNA damage-induced BRCA1 shuttling pptx

... DSBs BRCA1 NEFailed BRCA1 NEDeathMutation+Resistance BRCA1 BRCA1 BRCA1 Cell fate BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1Unrepairable DSBs BRCA1 BRCA1 BRCA1 ApoptosisFailed apoptosisOnOff BRCA1 Fig. ... apoptotic function bya mechanism involving nuclear retention. Exp Cell Res298, 661–673.12 Thompson ME (2010) BRCA1 16 years later: nuclear import and export processes. FEBS J 277, 3072–3078.13 Celeste ... BARD1, which binds and masks the BRCA1 NES to prevent BRCA1 nuclear export, inhibits BRCA1- mediated apoptosis [11]. Theapoptotic pathway stimulated by BRCA1 is indepen-dent of p53. BRCA1 also stimulates...

Báo cáo khoa học: BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications pptx

... 692–695.3 Thompson M (2010) BRCA1 16 years later: nuclear import and export processes. FEBS J 277, 3072–3078.4 Yang ES & Xia F (2010) BRCA1 16 years later: DNAdamage-induced BRCA1 shuttling. FEBS ... variant*DevelopmentQ1756InsCY1853STOPM1775K/RP1749RC64GT826K1835STOP340STOPSer1841Asn5083del19BARINGFig. 1. BRCA1 mutations and their cellular and physiological impact. (A) Domain structure of BRCA1 protein and the location of risk-associ-ated mutations discussed. NES, nuclear export signal; ... J. Linger and P. A. Kruk3096 FEBS Journal 277 (2010) 3086–3096 ª 2010 The Authors Journal compilation ª 2010 FEBSMINIREVIEW BRCA1 16 years later: risk-associated BRCA1 mutations and their functional...

Tài liệu Báo cáo khoa học: "A Syntactic Framework for Speech Repairs and Other Disruptions" doc

... hesitations (urn) and speech repairs (I mean) and give meta-comments on the ut- terance (right). specify how speech repairs should be handled by the parser. (Hindle, 1983) and (Bear et al., ... the input, and this view is readily imple- mentable. The repair metarule, when given the hypo- thetical start and end of a reparandum (say from a language model such as (Heeman and Allen, ... schubert@cs, rochester, edu Abstract This paper presents a grammatical and pro- cessing framework for handling the repairs, hesitations, and other interruptions in nat- ural human dialog. The proposed...

Báo cáo khoa học: "A Graphical Interface for MT Evaluation and Error Analysis" doc

... used to cal-culate Olbetween the reference and two candidatetranslations (boldface and underline indicate non-matched items in candidate 1 and 2, respectively).Similarly, metrics in another ... possible combination of metrics, systems,documents and segments. This kind of results isvaluable for rapid evaluation and ranking of trans-lations and systems. However, it is unfriendly forMT ... on the processes involved in theerror analysis stage in which MT developers need tounderstand the output of their systems and to assessthe improvements introduced.Automatic detection and classiﬁcation...

Báo cáo khoa học: "Searching Questions by Identifying Question Topic and Question Focus" docx

... question topic and question focus. More specifically, we first summarize questions in a data structure con-sisting of question topic and question focus. Then we model question topic and question ... Model (VSM) and Language Model for Information Retrieval (LMIR). 1 Introduction Over the past few years, online services have been building up very large archives of questions and their answers, ... traditional FAQ servic-es and emerging community-based Q&A services (e.g., Yahoo! Answers1, Live QnA2, and Baidu Zhidao3). To make use of the large archives of questions and their answers,...

Báo cáo khoa học: "ON THE INDEPENDENCE OF DISCOURSE STRUCTURE AND SEMANTIC DOMAIN" docx

... getting themaelves and their husbands and children off to work in the morning. (Linde, in preparation) These "morning routines" are typically well-structured and regular; everyone ... successive mention of each room and its position. This tour forms a tree composed of the entry to the apartment as root with the rooms and their locations as nodes, and with an associated pointer ... demonstrates the existence and organization of linguistic units larger than the sentence. (Chafe, 1974; Goguen, Linde, and Weiner, to appear; Grosz, 1977; Halliday and Hasan, 1976; Labov, 1972;...

Báo cáo khoa học: Systems biology: experimental design Clemens Kreutz and Jens Timmer docx

... errorsis ‘randomization’. Randomization means both, arandom allocation of the experimental material and a random order in which the individual runs of theexperiment are performed. Randomization ... Bioinformatics 18, 160 9 161 6.5 Churchill GA (2002) Fundamentals of experimentaldesign for cDNA microarrays. Nat Genet 32, 490–495.6 Kerr MK (2003) Design considerations for efﬁcient and effective ... efﬁcientexperimental planning requires that, on the one hand,theoreticians are able to appraise experimental feasi-bility and efforts and that, on the other hand, experi-menters know which kind of experimental...

Báo cáo khoa học: "Problems of Equivalence in Some German and English Constructions" doc

... for + NP2/case obj where x stands for specifiers of tense, number, and person and x' stands for the corresponding English morphological specifiers. NP stands for either a noun with its ... stands for a pronoun or a noun phrase containing one or more constituents. V stands for verb. Aux stands for the appropriate bound and free mor- phemes designating the number, tense, mood and ... and English verbs and constructions involving verbs. This study was concerned only with a restricted number of those German and English constructions which are both structurally similar and...

Báo cáo khoa học: "Improving Name Tagging by Reference Resolution and Relation Detection" docx

... (Bikel et al, 1997), but with multiple hy-potheses as output and a larger number of states (12) to handle name prefixes and suffixes, and transliterated foreign names separately. It operates on ... Evaluation Results 8.1 Training and Test Data We took 346 documents from the 2004 ACE train-ing corpus and official test set, including both broadcast news and newswire, as our blind test ... rules to correct some omissions and systematic errors using name lists (for example, a list of all Chinese last names; lists of organization and location suffixes) and par-ticular contextual patterns...

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