... Althoughsuccinylacetone and CoCl2are known inhibitors of hemebiosynthesis, these agents also elicit nonspecific and toxiceffects in animals. To ascertain that the effects of theseagents, on the catalytic ... shows the effects of hypoxia on the steadystate levels of nuclear genome encoded CytOX IV and VbmRNAs. There was no change in the levels of these mRNAs in macrophages at 6 h of hypoxia, the time ... [4,5]. The remaining 10 subunits of the mammalian enzyme, namely, IV, Vb, VIa, VIb, VIc, VIIa,VIIb and VIII are encoded by the nuclear genome,synthesized in the cytosol and imported into mitochondria[1–3]....