... in Parkin, presentin 50% of individuals with AR-JP, and 77% ofsporadic cases with disease onset before the age of 20[2]. Clinically, PD patients with mutations in PARK2suffer a slow progression ... Neuroscience, Institute of Neurology, University College London, UK Parkinson’s disease (PD) is a common neurode-generative disorder with no known cure, estimated toaffect 4 million people worldwide. ... pathway.AbbreviationsAR-JP, autosomal-recessive juvenile-onset Parkinson’s disease; HtrA2, HtrA serine peptidase 2; LRRK2, leucine-rich repeat kinase 2; PD, Parkinson’s disease; PINK1, PTEN-induced putative...