... previouslyto induce an increase in the level of [Ca2+]iand acorrelated calpain activation [28]. This increase in [Ca2+]iis more intense in aorta than in brain.Under these conditions, in brain, ... FEBShigher than in aorta, resulting in a much higherHSP90 to NOS ratio in brain (Fig. 1C).Calpain activation in rat brain and aortafollowing HSD treatmentTo promote in vivo calpain activation, ... calpain is carried out in the presence of HSP90 [27]. This finding can alsoexplain the large extent of digestion of eNOS in aorta, in which, in association with a higher degree of calpainactivation,...